Platelet lysate induces chondrogenic differentiation of umbilical cord‐derived mesenchymal stem cells by regulating the lncRNA H19/miR‐29b‐3p/SOX9 axis
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DOI: 10.1002/2211-5463.13002
Abstract: Platelet lysate (PL) has been shown to induce chondrogenic differentiation of human umbilical cord‐derived mesenchymal stem cells (hUCMSCs). However, the underlying mechanism is still not clear. The aim of this study was to investigate whether… read more here.
Keywords: h19 mir; chondrogenic differentiation; sox9; mir 29b ... See more keywords
Induction of Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Biomimetic Gold Nanoparticles with Tunable RGD Density
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DOI: 10.1002/adhm.201700317
Abstract: &NA; Nanostructured materials have drawn a broad attention for their applications in biomedical fields. Ligand‐modified nanomaterials can well mimic the dynamic extracellular matrix (ECM) microenvironments to regulate cell functions and fates. Herein, ECM mimetic gold… read more here.
Keywords: gold nanoparticles; rgd density; differentiation human; density ... See more keywords
Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly (ε-Caprolactone) Scaffolds.
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DOI: 10.1002/biot.201900078
Abstract: BACKGROUND Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical… read more here.
Keywords: bioreactor; perfusion culture; chondrogenic differentiation; perfusion ... See more keywords
O‐Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue‐engineering models
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DOI: 10.1002/term.1969
Abstract: Hypoxia has been shown to be important for maintaining cartilage homeostasis as well as for inducing chondrogenic differentiation. Ensuring low oxygen levels during in vitro culture is difficult, therefore we assessed the chondro‐inductive capabilities of… read more here.
Keywords: tissue engineering; chondrogenic differentiation; cartilage; phenanthroline ... See more keywords
Fibro/chondrogenic differentiation of dental stem cells into chitosan/alginate scaffolds towards temporomandibular joint disc regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6109-6
Abstract: AbstractTissue engineering (TE) may provide effective alternative treatment for challenging temporomandibular joint (TMJ) pathologies associated with disc malpositioning or degeneration and leading to severe masticatory dysfunction. Aim of this study was to evaluate the potential… read more here.
Keywords: temporomandibular joint; chondrogenic differentiation; differentiation dental; fibro chondrogenic ... See more keywords
The Combination of TGF-β3 and BMP-6 Synergistically Promotes the Chondrogenic Differentiation of Equine Bone Marrow-Derived Mesenchymal Stem Cells
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DOI: 10.1007/s10989-019-09880-w
Abstract: Stem cell therapy is a new approach in veterinary medicine for the treatment of complicated disorders such as articular cartilage injuries in horses. Although the equine bone marrow-derived mesenchymal stem cells (eBMSCs) have a unique capacity… read more here.
Keywords: bmp; bone; tgf; chondrogenic differentiation ... See more keywords
Promotive Role of CircATRNL1 on Chondrogenic Differentiation of BMSCs mediated by miR-338-3p.
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DOI: 10.1016/j.arcmed.2021.02.003
Abstract: AIM Bone marrow mesenchymal stem cells (BMSCs) are ideal seed cells for tissue engineering cartilage construction. However, the underlying mechanism of it has not been illuminate well. In this study, the effects of circATRNL1 (hsa_circ_0020093)… read more here.
Keywords: differentiation bmscs; chondrogenic differentiation; differentiation; mir 338 ... See more keywords
Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.136
Abstract: Treacher Collins syndrome (TCS) is a craniofacial developmental disorder whose key feature is a combination of symptoms. For example, a patient could have bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids,… read more here.
Keywords: tcs3 associated; collins syndrome; chondrogenic differentiation; differentiation ... See more keywords
Long noncoding RNA UCA1 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells via miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.140
Abstract: Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion… read more here.
Keywords: mirna 124; mirna; mirna 145; chondrogenic differentiation ... See more keywords
Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs.
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DOI: 10.1016/j.bbrc.2019.12.065
Abstract: In indirect co-culture system, chondrocytes can induce differentiation of bone marrow mesenchymal stem cells (BMSCs) to chondrocytes without additional inducer. The participation of microRNAs (miRNAs) may take part in the chondrogenic differentiation. Present study aimed… read more here.
Keywords: derived exosomal; mir 8485; differentiation; chondrogenic differentiation ... See more keywords
Long non-coding RNA MEG3 inhibits chondrogenic differentiation of synovium-derived mesenchymal stem cells by epigenetically inhibiting TRIB2 via methyltransferase EZH2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109379
Abstract: Osteoarthritis (OA) is a highly prevalent skeletal disease. Mesenchymal stem cell-derived cartilage tissue engineering is a clinical method used for OA treatment. Investigations on the molecular regulatory mechanisms of the chondrogenic differentiation of synovium-derived mesenchymal… read more here.
Keywords: meg3; chondrogenic differentiation; trib2; mesenchymal stem ... See more keywords