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   Articles with "chondroitin sulfate" as a keyword



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Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP‐3

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recommendations! Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13556

Abstract: Extracellular levels of soluble TIMP‐3 are low, reflecting its binding by extracellular matrix (ECM) components including sulfated glycosaminoglycans (SGAGs) and endocytosis via low density lipoprotein receptor‐related protein 1. Since TIMP‐3 inhibits ECM degradation, the ability… read more here.

Keywords: domain timp; chondroitin sulfate; timp; sulfate pentosan ... See more keywords
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An Instant Underwater Tissue Adhesive Composed of Catechin‐Chondroitin Sulfate and Cholesterol‐Polyethyleneimine

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recommendations! Published in 2023 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202202814

Abstract: Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions. In this study, a novel… read more here.

Keywords: tissue adhesive; sulfate cholesterol; chondroitin sulfate;
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Oral Bioavailability and Pharmacokinetics of Nonanimal Chondroitin Sulfate and Its Constituents in Healthy Male Volunteers

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recommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.587

Abstract: The pharmacokinetic profile of a new 800‐mg tablet of nonanimal chondroitin sulfate (CS) (Mythocondro®, 800‐mg tablets, Gnosis S.p.A., Italy) was investigated vs an animal CS in healthy volunteers for a total period of 48 hours.… read more here.

Keywords: oral bioavailability; charge density; nonanimal chondroitin; chondroitin sulfate ... See more keywords
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Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis

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recommendations! Published in 2018 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24127

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are… read more here.

Keywords: cspg receptors; chondroitin sulfate; amyotrophic lateral; expression ... See more keywords

Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans

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recommendations! Published in 2021 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24780

Abstract: Axonal damage and the subsequent interruption of intact neuronal pathways in the spinal cord are largely responsible for the loss of motor function after injury. Further exacerbating this loss is the demyelination of neighboring uninjured… read more here.

Keywords: chondroitin sulfate; oligodendrocyte progenitor; sulfate proteoglycans; neurotrophic factor ... See more keywords
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Remodeling Microenvironment for Endogenous Repair through Precise Modulation of Chondroitin Sulfate Proteoglycans Following Spinal Cord Injury.

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recommendations! Published in 2022 at "Small"

DOI: 10.1002/smll.202205012

Abstract: The fluid-filled cystic cavity sealed by a dense scar developed following traumatic spinal cord injury (SCI) has been a major obstacle to neural regeneration and functional recovery. Here the transected lesion is bridged using a… read more here.

Keywords: endogenous repair; cord injury; chondroitin sulfate; spinal cord ... See more keywords
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Chondroitin sulfate content and decorin expression in glioblastoma are associated with proliferative activity of glioma cells and disease prognosis

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recommendations! Published in 2019 at "Cell and Tissue Research"

DOI: 10.1007/s00441-019-03127-2

Abstract: Chondroitin sulfate proteoglycans (CSPGs) are important components of brain extracellular matrix (ECM), although their contribution in gliomagenesis remains underinvestigated. Here, both chondroitin sulfate (CS) content/distribution and expression of a number of CSPG core proteins were… read more here.

Keywords: gbm; content; chondroitin sulfate; expression ... See more keywords
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Low fouling strategy of electrochemical biosensor based on chondroitin sulfate functionalized gold magnetic particle for voltammetric determination of mycoplasma ovipneumonia in whole serum.

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recommendations! Published in 2020 at "Analytica chimica acta"

DOI: 10.1016/j.aca.2020.06.015

Abstract: Based on the successful design and preparation of Fe3O4@Au@polyethylene glycol (PEG)@chondroitin sulfate (CS) nanoparticles, a novel electrochemical biosensor was elaborately developed for MO determination by the drop coating method. This biosensor demonstrates ultra-low fouling properties… read more here.

Keywords: whole serum; biosensor; determination; electrochemical biosensor ... See more keywords
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Aggrecan-like biomimetic proteoglycans (BPGs) composed of natural chondroitin sulfate bristles grafted onto a poly(acrylic acid) core for molecular engineering of the extracellular matrix.

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recommendations! Published in 2018 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2018.05.013

Abstract: Biomimetic proteoglycans (BPGs) were designed to mimic the three-dimensional (3D) bottlebrush architecture of natural extracellular matrix (ECM) proteoglycans, such as aggrecan. BPGs were synthesized by grafting native chondroitin sulfate bristles onto a synthetic poly(acrylic acid)… read more here.

Keywords: engineering; sulfate bristles; tissue; chondroitin sulfate ... See more keywords
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Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

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recommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ajps.2018.09.004

Abstract: Folate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) and chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site.… read more here.

Keywords: delivery; colorectal cancer; chondroitin sulfate; chitosan chondroitin ... See more keywords
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Chondroitin sulfate-mediated albumin corona nanoparticles for the treatment of breast cancer

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recommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ajps.2021.03.004

Abstract: Chondroitin sulfate-mediated albumin corona nanoparticles were readily prepared without any chemical reaction, and their active tumor targeting and therapeutic effects were examined. Negatively charged chondroitin sulfate (CS) and positively charged doxorubicin (DOX) self-assembled into nanoparticles… read more here.

Keywords: albumin corona; dox nps; chondroitin sulfate; dox ... See more keywords