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   Articles with "chondroitinase abc" as a keyword



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Machine‐Assisted Discovery of Chondroitinase ABC Complexes toward Sustained Neural Regeneration

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recommendations! Published in 2022 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202102101

Abstract: Among the many molecules that contribute to glial scarring, chondroitin sulfate proteoglycans (CSPGs) are known to be potent inhibitors of neuronal regeneration. Chondroitinase ABC (ChABC), a bacterial lyase, degrades the glycosaminoglycan (GAG) side chains of… read more here.

Keywords: machine; regeneration; chondroitinase abc; toward sustained ... See more keywords
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Strategies for neurotrophin‐3 and chondroitinase ABC release from freeze‐cast chitosan–alginate nerve‐guidance scaffolds

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recommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"

DOI: 10.1002/term.1912

Abstract: Freeze casting, or controlled unidirectional solidification, can be used to fabricate chitosan–alginate (C–A) scaffolds with highly aligned porosity that are suitable for use as nerve‐guidance channels. To augment the guidance of growth across a spinal… read more here.

Keywords: nerve guidance; neurotrophin chondroitinase; guidance; chondroitinase abc ... See more keywords
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Recent advances in the therapeutic uses of chondroitinase ABC

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recommendations! Published in 2019 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2019.113032

Abstract: Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in laboratories worldwide and in several animal models. The… read more here.

Keywords: chondroitinase; delivery; chondroitinase abc; cord injury ... See more keywords

Improving the stability of chondroitinase ABC I via interaction with gold nanorods.

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recommendations! Published in 2018 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2017.08.167

Abstract: Chondroitinase ABC I (cABC I) cleaves glycosaminoglycan chains which are responsible for most of the inhibition of axon regrowth in spinal cord injury. The application of chondroitinase ABC I (cABC I) in damaged nervous tissue… read more here.

Keywords: chondroitinase abc; gold nanorods; stability; interaction ... See more keywords
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Efficient expression of chondroitinase ABC I for specific disaccharides detection of chondroitin sulfate.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2019.11.215

Abstract: Chondroitinase ABC I (ChSase ABC I) is a key enzyme of chondroitin sulfate (CS) degradation and widely used for CS detection in the medicine filed. However, the recombinant ChSase ABC I was weakly expressed in… read more here.

Keywords: chsase abc; expression; chondroitinase abc; specific disaccharides ... See more keywords
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Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2019.12.258

Abstract: Removal of chondroitin sulfate proteoglycans (CSPGs) with chondroitinase ABC I (ChABC) facilitates axonal plasticity, axonal regeneration and remyelination, following injury to the central nervous system (CNS). However, the ChABC rapidly undergoes thermal inactivity and needs… read more here.

Keywords: psi; myelin repair; chabc psi; porous silicon ... See more keywords

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury

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recommendations! Published in 2018 at "Brain"

DOI: 10.1093/brain/awy007

Abstract: See Moon and Bradbury (doi:10.1093/brain/awy067) for a scientific commentary on this article.Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new… read more here.

Keywords: chondroitinase abc; chondroitinase; cord injury; spinal cord ... See more keywords
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Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0182339

Abstract: Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of whom are in the chronic phase of their injury. Unfortunately, most current treatments target the acute/subacute injury phase as the microenvironment of… read more here.

Keywords: cord; chondroitinase abc; stem; injury ... See more keywords