Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13102
Abstract: Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging and anatomical location, is not reliable and more objective biomarkers… read more here.
Keywords: chondrosarcoma; ctdna; tumour dna; circulating tumour ... See more keywords
Familial solitary chondrosarcoma resulting from germline EXT2 mutation
Sign Up to like & getrecommendations! Published in 2017 at "Genes"
DOI: 10.1002/gcc.22419
Abstract: Germline mutations of EXT2, encoding Exostosin Glycosyltransferase 2, are associated with multiple osteochondromas (MO), an autosomal dominant disease characterized by the development of multiple peripheral cartilaginous benign tumors with a weak risk of malignant transformation.… read more here.
Keywords: chondrosarcoma; germline ext2; ext2 mutation; development ... See more keywords
Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23153
Abstract: Chondrosarcoma is the second most common form of bone cancer and is characterized by its ability to produce an extracellular matrix of the cartilage. Highâgrade chondrosarcoma is highly aggressive and can metastasize to other parts… read more here.
Keywords: chondrosarcoma; fibroblast growth; chondrosarcoma cells; resistance ... See more keywords
Intralesional vs. extralesional procedures for low-grade central chondrosarcoma: a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-018-2930-0
Abstract: IntroductionChondroid lesions are very common bone tumors. In most cases, they are benign enchondromas (EC) and, in a minor percentage, chondrosarcomas (CSs), the malignant counterpart. In the latter cases, surgery is the mainstay treatment, because… read more here.
Keywords: chondrosarcoma; review literature; low grade; resection ... See more keywords
Angiogenesis-Targeted 68Ga-DOTA-RGD2 PET/CT Imaging: a Potential Theranostic Application in the Case of Chondrosarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-021-00691-w
Abstract: Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in cases of non-resectable and recurrent… read more here.
Keywords: chondrosarcoma; 68ga dota; pet; angiogenesis ... See more keywords
Coexistence of secondary chondrosarcoma and lung carcinoma metastasis in the humerus of a patient with Ollier's disease: A case report
Sign Up to like & getrecommendations! Published in 2019 at "Acta Orthopaedica et Traumatologica Turcica"
DOI: 10.1016/j.aott.2018.10.008
Abstract: Tumor-to-tumor metastasis in the same bone is an extremely rare condition. Limited number of case reports exists for coincidence of benign and malign neoplasms but none for malignant to malignant metastasis. Occurrence of several individual… read more here.
Keywords: chondrosarcoma; ollier disease; case; metastasis ... See more keywords
The diagnostic significance of pulmonary nodules on CT thorax in chondrosarcoma of bone.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical radiology"
DOI: 10.1016/j.crad.2019.11.017
Abstract: AIM To provide a diagnostic approach to pulmonary nodules in patients with chondrosarcoma. MATERIALS AND METHODS A search of the oncology database at a specialist orthopaedic oncology referral centre was performed to identify all patients… read more here.
Keywords: chondrosarcoma; diagnostic significance; pulmonary nodules; patients grade ... See more keywords
Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report
Sign Up to like & getrecommendations! Published in 2017 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2016.12.013
Abstract: Primary mesenchymal chondrosarcoma of the Kidney is an extremely rare entity and very few cases have been reported in literature. We report a 22-year-old male with a right renal mass; after radical nephrectomy, pathologic examination… read more here.
Keywords: chondrosarcoma; skeletal mesenchymal; extra skeletal; report ... See more keywords
Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.03.014
Abstract: Mesenchymal chondrosarcoma is rare and can be challenging to diagnose. Herein, we report a minute mesenchymal chondrosarcoma within an osteochondroma. A 12-year-old girl presented with an asymptomatic exophytic lesion of the rib. The tumor was… read more here.
Keywords: chondrosarcoma; within osteochondroma; chondrosarcoma within; mesenchymal chondrosarcoma ... See more keywords
Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2017.03.016
Abstract: The primary mammary chondrosarcoma corresponds to less than 0,5% of the mammary malignancies. For the period ranging from 1967 to 2014, only 18 cases were reported in the literature. A 41 year old woman found… read more here.
Keywords: chondrosarcoma; breast; sparing mastectomy; nipple sparing ... See more keywords
Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone Oncology"
DOI: 10.1016/j.jbo.2019.100222
Abstract: Background Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in chondrosarcoma. Methods A… read more here.
Keywords: chondrosarcoma; chondrosarcoma cell; inhibition; pathway ... See more keywords