Growth Inhibition and Induction of Innate Immune Signaling of Chondrosarcomas with Epigenetic Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-21-0066
Abstract: Chondrosarcomas are inherently resistant to chemotherapy and radiotherapy, pointing to an unmet need for new treatment options. Immune checkpoint inhibitors, which have shown remarkable promise in multiple solid cancer types, have limited efficacy in chondrosarcomas.… read more here.
Keywords: innate immune; inhibition; chondrosarcomas; aza saha ... See more keywords
Expression profiles of angiogenesis in two high grade chondrosarcomas: A xenotransplant experience in nude mice.
Sign Up to like & getrecommendations! Published in 2017 at "Histology and histopathology"
DOI: 10.14670/hh-11-880
Abstract: BACKGROUND Chondrosarcomas (Chs) are malignant cartilage-forming tumors that represent the third most common malignant solid tumor of bone in adults. Angiogenesis is a major factor for tumor growth and metastasis. Our aim was to make… read more here.
Keywords: chondrosarcomas; high grade; expression profiles; grade ... See more keywords
Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
Sign Up to like & getrecommendations! Published in 2023 at "Cell reports"
DOI: 10.2139/ssrn.4229509
Abstract: Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting… read more here.
Keywords: glycogen metabolism; idh1; mutant idh; cartilage ... See more keywords
Structural Features of Heparan Sulfate from Multiple Osteochondromas and Chondrosarcomas
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DOI: 10.3390/molecules23123277
Abstract: Multiple osteochondromas (MO) is a hereditary disorder associated with benign cartilaginous tumors, known to be characterized by absence or highly reduced amount of heparan sulfate (HS) in the extracellular matrix of growth plate cartilage, which… read more here.
Keywords: sulfate multiple; chondrosarcomas; multiple osteochondromas; features heparan ... See more keywords
Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas
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DOI: 10.6061/clinics/2021/e2914
Abstract: OBJECTIVES: The aim of this study was to evaluate the role of amphiregulin protein, an epidermal growth factor receptor ligand, in cartilaginous tumors. METHODS: Amphiregulin expression was examined in 31 enchondromas and 67 chondrosarcomas using… read more here.
Keywords: chondrosarcomas; long bones; expression; short bones ... See more keywords