Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13652
Abstract: Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin-like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression,… read more here.
Keywords: bone; kielin chordin; bone morphogenetic; differentiation ... See more keywords
Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury
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DOI: 10.1038/s41598-022-08031-4
Abstract: Ischemic injury occurs when the brain is deprived of blood flow, preventing cells from receiving essential nutrients. The injury core is the brain region directly deprived and is surrounded by the peri-infarct area, the region… read more here.
Keywords: infarct area; chordin like; injury; peri infarct ... See more keywords
Chordin like-1 regulates osteoblast and adipocyte differentiation through stabilizing insulin-like growth factor binding protein 3.
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DOI: 10.1093/stmcls/sxad009
Abstract: Chordin like-1 (CHRDL1) is an antagonist of bone morphogenetic proteins (BMPs) that acts through binding BMPs and blocking their interaction with BMP receptors. CHRDL1 plays a role in osteoblast differentiation but controversial effects were reported.… read more here.
Keywords: adipocyte differentiation; insulin like; like growth; differentiation ... See more keywords
Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway
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DOI: 10.3389/fendo.2019.00360
Abstract: Chordin-like 1 (CHRDL1) is a secreted glycoprotein with repeated cysteine-rich domains, which can bind to BMPs family ligands. Although it has been reported to play important roles in several systems, the exact roles of CHRDL1… read more here.
Keywords: hbmscs; chrdl1; bone; osteogenic differentiation ... See more keywords
Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma
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DOI: 10.3389/fonc.2022.862751
Abstract: Background Accumulating evidence suggests that dysregulation of Chordin-like 1 (CHRDL1) is associated with malignant biological behaviors in multiple cancers. However, the exact function and molecular mechanism of CHRDL1 in oral squamous cell carcinoma (OSCC) remain… read more here.
Keywords: metastasis; cell; signaling pathway; mapk signaling ... See more keywords