Molecular characteristics of poorly differentiated chordoma
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22782
Abstract: Pediatric poorly differentiated chordoma is a subtype of chordoma with a much more aggressive clinical course and has been characterized by loss of SMARCB1. This study characterizes the molecular features of these tumors in comparison… read more here.
Keywords: differentiated chordoma; poorly differentiated; characteristics poorly; molecular characteristics ... See more keywords
Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24427
Abstract: Chordoma is a rare bone tumor with genetic risk factors largely unknown. We conducted a whole‐exome sequencing (WES) analysis of germline DNA from 19 familial chordoma cases in five pedigrees and 137 sporadic chordoma patients… read more here.
Keywords: germline variants; palb2 brca2; germline; chordoma ... See more keywords
Clinicopathological implications of TIM3+ tumor-infiltrating lymphocytes and the miR-455-5p/Galectin-9 axis in skull base chordoma patients
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02349-1
Abstract: Chordoma is difficult to eradicate due to high local recurrence rates. The immune microenvironment is closely associated with tumor prognosis; however, its role in skull base chordoma is unknown. The expression of Galectin-9 (Gal9) and… read more here.
Keywords: mir 455; base chordoma; chordoma; skull base ... See more keywords
[Cervical paraspinal chordoma, a condition we should know. A case report].
Sign Up to like & getrecommendations! Published in 2017 at "Neurocirugia"
DOI: 10.1016/j.neucir.2017.01.002
Abstract: Chordoma is a rare, slow-growing tumour arising from remnants of the notochord. It is most often located in the base of the skull and the sacrococcygeal region, being located in the cervical region in only… read more here.
Keywords: cervical paraspinal; chordoma condition; case; condition know ... See more keywords
5-Aminolevulinic acid-based photodynamic therapy of chordoma: In vitro experiments on a human tumor cell line.
Sign Up to like & getrecommendations! Published in 2017 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2017.09.011
Abstract: BACKGROUND Chordomas are very rare tumors of the skull base and the sacrum. They show infiltrating and destructive growth and are known to be chemo- and radio-resistant. After surgical resection, the recurrence rate is high… read more here.
Keywords: photodynamic therapy; ala; aminolevulinic acid; cell ... See more keywords
Nomogram for Individualized Prediction and Prognostic Factors for Survival in Patients with Primary Spinal Chordoma: A Population-Based Longitudinal Cohort Study.
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2019.04.217
Abstract: BACKGROUND Chordoma is a type of rare bone tumor and is a relatively slow-growing, low-grade malignancy that is locally invasive and aggressive. The nomogram is widely used in the field of cancer because it can… read more here.
Keywords: primary spinal; prognostic factors; spinal chordoma; patients primary ... See more keywords
Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy.
Sign Up to like & getrecommendations! Published in 2020 at "World neurosurgery"
DOI: 10.1016/j.wneu.2020.08.021
Abstract: Chordomas are rare, locally malignant tumors derived from remnants of the notochord that can manifest anywhere in the spine or base of the skull. Surgical treatment for chordomas of the lumbar spine often fails to… read more here.
Keywords: ultrasonic osteotomy; navigated ultrasonic; bloc; spondylectomy ... See more keywords
Genes predicting survival of chordoma patients.
Sign Up to like & getrecommendations! Published in 2021 at "World neurosurgery"
DOI: 10.1016/j.wneu.2021.09.027
Abstract: PURPOSE A chordoma is a slow-growing, invasive neoplasm in the neuraxis, thought to arise from notochordal cells. At 10-year follow-up, the average survival rate is 50%, though the interindividual prognosis varies substantially. Here, we aim… read more here.
Keywords: chordoma patients; free survival; predicting survival; genes predicting ... See more keywords
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature medicine"
DOI: 10.1038/s41591-018-0312-3
Abstract: Chordoma is a primary bone cancer with no approved therapy1. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors2,3. Here… read more here.
Keywords: transcription factor; transcription; small molecule; chordoma ... See more keywords
Fingolimod inhibits proliferation and epithelial–mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200221
Abstract: Abstract Purpose: To explore the sensitivity of the immunosuppressive agent fingolimod (FTY720) in chordoma and determine whether it can serve as an appropriate alternate treatment for unresectable tumours in patients after incomplete surgery. Methods: Cell… read more here.
Keywords: stat3 signalling; chordoma; sacral chordoma; epithelial mesenchymal ... See more keywords
TOMM20 as a Potential Prognostic Biomarker in Chordoma: Results From a High-Volume, Single-Center Study.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac180
Abstract: OBJECTIVES As few large studies identify correlative biomarkers in chordoma, our objective was to use our large, single-center chordoma tumor bank to identify novel signaling pathways. METHODS Clinical and pathologic data for 73 patients with… read more here.
Keywords: primary lesions; chordoma; tomm20 potential; single center ... See more keywords