Inhibition of miR-140-3p or miR-155-5p by antagomir treatment sensitize chordoma cells to chemotherapy drug treatment by increasing PTEN expression.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.03.034
Abstract: Previous researches suggested microRNA-140-3p (miR-140-3p) and miR-155-5p as cancer promotor in chordoma. We aimed to investigate the mechanisms of these two miRNAs in chordoma cells. Patient-derived chordoma cell lines were established in vitro. Expressions of… read more here.
Keywords: mir 155; chordoma cells; treatment; 140 mir ... See more keywords
LOC554202 contributes to chordoma progression by sponging miR-377-3p and up-regulating SMAD3
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001327
Abstract: Chordoma is a rare malignant bone tumor originating from the remnants of the notochord. Here, the role of long noncoding LOC554202 in chordoma progression and its associated mechanism were explored. Cell proliferation was analyzed by… read more here.
Keywords: chordoma; mir 377; loc554202; chordoma cells ... See more keywords
miR-100-5p Inhibits Malignant Behavior of Chordoma Cells by Targeting IGF1R
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s252185
Abstract: Purpose Our research aimed to illuminate the role of miR-100-5p in chordoma and potential mechanism. Materials and Methods We used microRNA array analysis to explore differentially expressed miRNAs in chordoma tissue and then verified by… read more here.
Keywords: chordoma cells; 100 inhibits; chordoma; targeting igf1r ... See more keywords
LncRNA XIST Promotes Growth of Human Chordoma Cells by Regulating miR-124-3p/iASPP Pathway
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s252195
Abstract: Introduction Chordoma is a malignant primary bone tumor that is found in the spine and skull. X-inactive specific transcript (XIST) is a long non-coding RNA (lncRNA) is known to be involved in the development of… read more here.
Keywords: chordoma cells; lncrna xist; chordoma; human chordoma ... See more keywords