Descriptive epidemiology of chordomas in the United States
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03511-x
Abstract: Purpose Chordomas account for 1% to 4% of all bone malignancies and 0.5% of all primary intracranial central nervous system tumors. Prior epidemiologic literature is based on limited population data. The purpose of this study is… read more here.
Keywords: incidence; epidemiology chordomas; age; descriptive epidemiology ... See more keywords
Surgery and Proton Radiation Therapy for Pediatric Base of Skull Chordomas: Long-term Clinical Outcomes for 204 patients.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noad068
Abstract: BACKGROUND Data on clinical outcomes for base of skull (BOS) chordomas in the pediatric population is limited. We report patient outcomes after surgery and proton radiotherapy (PRT). METHODS Pediatric patients with BOS chordomas were treated… read more here.
Keywords: clinical outcomes; proton; surgery proton; base skull ... See more keywords
GENE-01. THE MUTATIONAL LANDSCAPE OF PRIMARY CHORDOMAS AND THEIR SENSITIVE DETECTION IN PLASMA ctDNA BY MULTIPLE NEXT GENERATION SEQUENCING TECHNOLOGIES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.403
Abstract: CNS-associated tumors are notoriously difficult to detect in plasma. Chordomas are the most common primary spinal column malignancy, and extensive surgical procedures, along with chemotherapy and radiation are required to reduce recurrence. Currently CT, MRI,… read more here.
Keywords: mutational landscape; ctdna; detection; biopsy ... See more keywords
The clinical outcome of recurrent sacral chordoma with further surgical treatment
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DOI: 10.1097/md.0000000000013730
Abstract: Abstract Case series. To analyze the clinical results and related factors of further surgical treatment for recurrent sacral chordomas. Chordomas are rare primary malignant tumors with a high recurrence rate. The treatment of recurrent tumors… read more here.
Keywords: surgical treatment; recurrence; treatment; recurrent sacral ... See more keywords
Management of Chordoma of the Sacrum and Mobile Spine
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DOI: 10.2106/jbjs.rvw.22.00162
Abstract: ➢ Chordomas account for 1% to 4% of primary tumors of the spine and sacrum.➢ En bloc resection is the preferred surgical treatment for the management of chordomas.➢ Proton beam radiation is increasingly being used… read more here.
Keywords: chordoma sacrum; mobile spine; management chordoma; management ... See more keywords
Stereotactic radiosurgery for intracranial chordomas: an international multiinstitutional study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurosurgery"
DOI: 10.3171/2021.12.jns212416
Abstract: OBJECTIVE The object of this study was to evaluate the safety, efficacy, and long-term outcomes of stereotactic radiosurgery (SRS) in the management of intracranial chordomas. METHODS This retrospective multicenter study involved consecutive patients managed with… read more here.
Keywords: tumor; chordomas; stereotactic radiosurgery; study ... See more keywords
Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study
Sign Up to like & getrecommendations! Published in 2023 at "Neurosurgical Focus"
DOI: 10.3171/2023.3.focus22653
Abstract: Chordomas are rare tumors from notochordal remnants and account for 1%–4% of all primary bone malignancies, often arising from the clivus and sacrum. Despite margin-negative resection and postoperative radiotherapy, chordomas often recur. Further, immunohistochemical (IHC)… read more here.
Keywords: long term; term recurrence; recurrence; resection ... See more keywords
Clinical Grading System, Surgical Outcomes and Prognostic Analysis of Cranial Base Chordomas
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DOI: 10.3340/jkns.2021.0240
Abstract: Objective Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression… read more here.
Keywords: survival; recurrence; grading system; base chordomas ... See more keywords
Circulating tumor DNA – A potential aid in the management of chordomas
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DOI: 10.3389/fonc.2022.1016385
Abstract: Chordomas are a locally invasive, low-grade, CNS malignancy that are primarily found in the skull base, spine, and sacrum. They are thought to be derived from notochordal remnants and remain a significant clinical challenge due… read more here.
Keywords: circulating tumor; management; tumor dna; tumor ... See more keywords
Multimodal Intraoperative Image-Driven Surgery for Skull Base Chordomas and Chondrosarcomas
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DOI: 10.3390/cancers14040966
Abstract: Simple Summary Achieving gross total resection during the first surgical intervention is particularly important for chondrosarcomas and chordomas, as recurrences are frequently impossible to resect due to post-surgical and post-radiation scarring and vascular fragility. Despite… read more here.
Keywords: image; chordomas; resection; skull base ... See more keywords
Prognostic Relevance and In Vitro Targeting of Concomitant PTEN and p16 Deficiency in Chordomas
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DOI: 10.3390/cancers15071977
Abstract: Simple Summary Chordomas are rare malignant bone tumors that predominantly occur along the spine. The most frequent alterations include the loss of PTEN and p16 proteins. While both oncoproteins have been investigated as independent prognostic… read more here.
Keywords: loss pten; p16 deficiency; pten p16; chordomas ... See more keywords