Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5243
Abstract: Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study aimed to identify… read more here.
Keywords: choriocarcinoma; drug library; novel therapeutic; library screening ... See more keywords
Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound‐guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.23719
Abstract: We describe a case of a 41‐year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas… read more here.
Keywords: guided fine; ischemic attack; choriocarcinoma; fine needle ... See more keywords
Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4-mediated epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23363
Abstract: Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor. The effect of rolipram on the metastasis of choriocarcinoma is barely known. Here, we evaluated the role of rolipram in the migration and invasion of human choriocarcinoma cells… read more here.
Keywords: choriocarcinoma cells; choriocarcinoma; rolipram; migration invasion ... See more keywords
Lidocine potentiates the cytotoxicity of 5‐fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28913
Abstract: Choriocarcinoma is a gestational trophoblastic cancer, which often occurs in the first 3 months of pregnancy. 5‐Fluorouracil (5‐Fu) is the widely used chemotherapeutic drug for choriocarcinoma but limited by drug resistance. Lidocaine, an aminamide‐type anesthetic,… read more here.
Keywords: jeg jar; choriocarcinoma; cells downregulating; cytotoxicity ... See more keywords
Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25637
Abstract: As a major dietary flavonol, quercetin mitigates proliferation and progression of cancer due to its anti‐angiogenic, anti‐inflammatory, anti‐oxidant, and apoptotic biological effects on cells. Although its apoptotic effects have been reported for various cancers, little… read more here.
Keywords: jeg3 cells; choriocarcinoma; jar jeg3; mapk signal ... See more keywords
Characterization of the role of NLRP7 protein in normal and tumor pregnancies: Case of Choriocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.367
Abstract: Choriocarcinoma is a veritable placental cancer that develops upon abnormal pregnancies named Hydatidiform Moles (HMs). Choriocarcinoma can metastasis in multiple maternal organs, such as lungs and the brain. Recent studies established an association between recurrent… read more here.
Keywords: choriocarcinoma; demonstrated nlrp7; role; nlrp7 protein ... See more keywords
Chrysin disrupts intracellular homeostasis through mitochondria-mediated cell death in human choriocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.109
Abstract: The trophoblast cells which form the placenta, have a high potential for invading other tissues. Owing to certain mechanisms, trophoblast cells may lose their ability to control cell proliferation, and develop into pregnancy-related tumors, known… read more here.
Keywords: chrysin disrupts; choriocarcinoma; intracellular homeostasis; disrupts intracellular ... See more keywords
Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2020.100625
Abstract: Highlights • Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death.• High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma.• Pembrolizumab should be considered for salvage therapy for… read more here.
Keywords: choriocarcinoma pembrolizumab; salvage therapy; choriocarcinoma; checkpoint ... See more keywords
Rapid recurrence of primary gastric choriocarcinoma after complete resection
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2019.03.045
Abstract: Highlights • A 78-year-old man was diagnosed with stage cIB primary gastric choriocarcinoma.• Total gastrectomy with spleen-preserving D2 lymphadenectomy was performed.• Early recurrence was diagnosed 3 months postoperatively.• The patient underwent a standard nongestational choriocarcinoma… read more here.
Keywords: choriocarcinoma; recurrence primary; rapid recurrence; primary gastric ... See more keywords
Extrauterine Choriocarcinoma in the Fallopian Tube Following Infertility Treatment: Implications for the Management of Early-Detected Ectopic Pregnancies.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of minimally invasive gynecology"
DOI: 10.1016/j.jmig.2017.03.006
Abstract: Extrauterine choriocarcinoma in the fallopian tube is very rare and is often diagnosed and treated as an ectopic tubal pregnancy. A 34-year-old woman who initially became pregnant after infertility treatment using ovulation induction with clomiphene… read more here.
Keywords: choriocarcinoma; fallopian tube; treatment; extrauterine choriocarcinoma ... See more keywords
379. Choriocarcinoma in a 27 week pregnancy
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.414
Abstract: Introduction We present a 41 year old female, HIV positive, on antiretroviral therapy with a CD4 count of 387 and a suppressed viral load. She was diagnosed and treated for tuberculosis in 2008. She presented with… read more here.
Keywords: pregnancy; choriocarcinoma; chest; 379 choriocarcinoma ... See more keywords