Unraveling the possible inhibitors for Chorismate synthase to combat tuberculosis using in silico approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2039298
Abstract: Abstract Tuberculosis antibiotic resistance is a huge concern to the global population. The goal of this study was to find new and effective compounds to treat multidrug-resistant tuberculosis by targeting Chorismate synthase (CS), a crucial… read more here.
Keywords: chorismate synthase; unraveling possible; tuberculosis; possible inhibitors ... See more keywords
Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid dependent autophagy response in parasite.
Sign Up to like & getrecommendations! Published in 2020 at "Biology open"
DOI: 10.1242/bio.054544
Abstract: Cerebral malaria caused by P. falciparum is the severest form of the disease resulting into morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality… read more here.
Keywords: cerebral malaria; salicylic acid; parasite; chorismate synthase ... See more keywords
A HR-MS Based Method for the Determination of Chorismate Synthase Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Protein and peptide letters"
DOI: 10.2174/0929866523666161222153707
Abstract: Chorismate synthase (Cs) catalyzes the last step of Shikimate pathway involving a unique biochemical reaction of anti-1,4 elimination of 3-phosphate group and the C-(6proR) hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) leading to the formation of chorismate, which… read more here.
Keywords: based method; activity; chorismate; chorismate synthase ... See more keywords