A Novel “Inside‐Out” Intraocular Nanomedicine Delivery Mode for Nanomaterials’ Biological Effect Enhanced Choroidal Neovascularization Occlusion and Microenvironment Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202209690
Abstract: Photodynamic therapy (PDT) is commonly used in choroidal neovascularization (CNV) treatment due to the superior light transmittance of the eye. However, PDT often leads to surrounding tissue damage and further microenvironmental deterioration, including exacerbated hypoxia,… read more here.
Keywords: microenvironment; cnv; occlusion; choroidal neovascularization ... See more keywords
Rationally Engineering Pro‐Proteins and Membrane‐Penetrating α‑Helical Polypeptides for Genome Editing Toward Choroidal Neovascularization Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202412366
Abstract: Ribonucleoprotein (RNP)‐based CRISPR/Cas9 genome editing holds great potential for the treatment of choroidal neovascularization (CNV), which however, is challenged by the lack of efficient cytosolic protein delivery tools. Herein, reversibly‐phosphorylated pro‐proteins (P‐proteins) with conjugated adenosine… read more here.
Keywords: treatment; membrane penetrating; genome editing; pro proteins ... See more keywords
Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK
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DOI: 10.1002/advs.202400747
Abstract: Neovascular age‐related macular degeneration (NVAMD) is a common retinal disease causing vision loss in the elderly. Neuroinflammation significantly contributes to NVAMD's etiology. This study explores the role of Programmed cell death ligand 1 (PD‐L1), an… read more here.
Keywords: neovascularization; vascular leakage; immune checkpoint; neovascularization via ... See more keywords
Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti-VEGFA Nanobody and Proprietary Penetratin Analog Formulation.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202504660
Abstract: Pathological retinal and choroidal neovascularization is a hallmark of several blinding diseases, including diabetic retinopathy and age‐related macular degeneration. While intravitreal anti‐VEGF therapies remain the standard of care, they necessitate frequent injections, posing risks such… read more here.
Keywords: neovascularization; anti vegfa; retinal choroidal; pathological retinal ... See more keywords
Silencing of YAP attenuates pericyte‐myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11809
Abstract: Age‐related macular degeneration (AMD) is the main reason of irreversible vision loss in the elderly. The subretinal fibrosis subsequent to choroidal neovascularization (CNV) is an important feature in the late stage of wet AMD and… read more here.
Keywords: pericyte myofibroblast; subretinal fibrosis; cnv; choroidal neovascularization ... See more keywords
Silencing fibroblast growth factor 7 inhibits krypton laser‐induced choroidal neovascularization in a rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28652
Abstract: Choroidal neovascularization (CNV), a characteristic of age‐related macular degeneration, is an underlying cause of severe vision loss among elderly patients. Fibroblast growth factor (FGF) is suggested to exert an important role in the pathogenesis of… read more here.
Keywords: growth factor; fgf7; cnv; choroidal neovascularization ... See more keywords
MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207335
Abstract: Age-related macular degeneration (AMD), especially wet AMD with choroidal neovascularization (CNV), commonly causes blindness in older patients and disruption of the choroid followed by second-wave injuries, including chronic inflammation, oxidative stress, and excessive matrix metalloproteinase… read more here.
Keywords: oxide quantum; mmp9 responsive; micro drug; choroidal neovascularization ... See more keywords
Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1683-0
Abstract: Aberrant growth of blood vessels in the choroid layer of the eye, termed choroidal neovascularization (CNV), is the pathological hallmark of exudative age-related macular degeneration (AMD), causing irreversible blindness among the elderly. Co-localization of proangiogenic… read more here.
Keywords: hypoxia; vector; choroidal neovascularization; gene therapy ... See more keywords
Ranibizumab for choroidal neovascularization secondary to pseudoxanthoma elasticum: 4-year results from the PIXEL study in France
Sign Up to like & getrecommendations! Published in 2017 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-017-3685-y
Abstract: PurposeTo evaluate the long-term effectiveness and safety of ranibizumab 0.5 mg in patients with choroidal neovascularization (CNV) secondary to pseudoxanthoma elasticum (PXE) in a real-world setting.MethodsA descriptive, observational, multicenter study in a retrospective and prospective cohort… read more here.
Keywords: choroidal neovascularization; ranibizumab; year; safety ... See more keywords
Choroidal neovascularization secondary to pathological myopia—macular Bruch membrane defects as prognostic factor to anti-VEGF treatment
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05142-y
Abstract: To evaluate the prevalence and visual outcomes of macular Bruch membrane (BM) defects in patients treated with anti-vascular endothelial growth factors (VEGF) for choroidal neovascularization secondary to pathological myopia (mCNV). Single-center retrospective observational case series… read more here.
Keywords: anti vegf; macular bruch; choroidal neovascularization; bruch membrane ... See more keywords
Choroidal neovascularization after an alexandrite laser burn
Sign Up to like & getrecommendations! Published in 2019 at "Lasers in Medical Science"
DOI: 10.1007/s10103-019-02881-7
Abstract: Lasers used for hair removal operate between 700 and 1000 nm to be absorbed by hair follicle melanin and destroyed by thermal injury [1]. Due to the high concentration of melanin in the retinal pigment… read more here.
Keywords: choroidal neovascularization; laser burn; neovascularization alexandrite; alexandrite laser ... See more keywords