CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5
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DOI: 10.1002/glia.24003
Abstract: It is well recognized that astrocytes can produce factors known to affect the myelination process. One such factor, brain‐derived neurotrophic factor (BDNF), can enhance the differentiation of oligodendrocyte lineage cells following a demyelinating lesion. Our… read more here.
Keywords: myelin proteins; metabotropic glutamate; myelination; chpg ... See more keywords
The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation
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DOI: 10.1186/s40478-025-02124-7
Abstract: Previous studies in adult mice indicate that the mGluR5 agonist 2-chloro-5-hydroxyphenyl glycine (CHPG), reduces cuprizone-elicited losses in myelin. This effect is partly mediated by CHPG binding to mGluR5 receptors on reactive astrocytes, triggering the release… read more here.
Keywords: differentiation; enhances human; chpg enhances; agonist chpg ... See more keywords