Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer
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DOI: 10.3390/cancers14102397
Abstract: Simple Summary Our work establishes that amplification of 4EBP1, as a part of Chr. 8p11, creates a synthetic dependency on FGFR1 signaling in cancer. 4EBP1 is phosphorylated by FGFR1 and PI3K signaling, and accordingly cancer… read more here.
Keywords: pi3k; fgfr1; amplification; chr 8p11 ... See more keywords