Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13208
Abstract: The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα and ChREBPβ. However,… read more here.
Keywords: suppresses expression; expression chrebp; hepg2 cells; hepg2 ... See more keywords
Hepatic ChREBP activation limits NAFLD development in a mouse model for Glycogen Storage Disease type Ia.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31198
Abstract: Glycogen storage disease type Ia (GSD Ia) is an inborn error of metabolism caused by defective glucose-6-phosphatase (G6PC) activity. GSD Ia patients exhibit severe hepatomegaly due to glycogen and triglyceride (TG) accumulation in the liver.… read more here.
Keywords: storage; glycogen; disease; nafld development ... See more keywords
A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04178-2
Abstract: The carbohydrate response element binding protein (ChREBP) is a glucose-responsive transcription factor that increases the transcription of multiple genes. ChREBP is highly localized in the liver, where it upregulates the expression of genes that code… read more here.
Keywords: bat chrebp; adipose tissue; mice; chrebp ... See more keywords
PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103766
Abstract: Summary Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-exposed… read more here.
Keywords: accumulation; fatty acid; phlpp1 promotes; chrebp ... See more keywords
Development of an effective and rapid qPCR for identifying human ChREBPα/β isoforms in hepatic and adipose tissues
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2019.1581944
Abstract: Abstract Most quantitative real-time PCR (qPCR) detection methods use two types of chemistries to measure the expression levels of ChREBP isoforms, hydrolysis probes for ChREBPα and SYBR Green for ChREBPβ. Hydrolysis probes are not available… read more here.
Keywords: qpcr; chrebp isoforms; development effective; hydrolysis probes ... See more keywords
Carb-Loading: Freeze-Induced Activation of the Glucose-Responsive ChREBP Transcriptional Network in Wood Frogs
Sign Up to like & getrecommendations! Published in 2020 at "Physiological and Biochemical Zoology"
DOI: 10.1086/706463
Abstract: The freeze-tolerant wood frog, Rana sylvatica, is one of few vertebrate organisms that can tolerate freezing, with up to 70% of its total body water being converted into extracellular ice. Physiologically, wood frogs show no… read more here.
Keywords: liver tissue; wood frogs; activity; wood ... See more keywords
Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac061
Abstract: ABSTRACT Previous studies have indicated an association of fat mass and obesity-associated (FTO) with nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. This study aimed to decipher the complex role of… read more here.
Keywords: methylation; srebf1 chrebp; fto; chrebp ... See more keywords
ChREBPβ is dispensable for the control of glucose homeostasis and energy balance
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.153431
Abstract: Impaired glucose metabolism is observed in obesity and type 2 diabetes. Glucose controls gene expression through the transcription factor ChREBP in liver and adipose tissues. Mlxipl encodes 2 isoforms: ChREBPα, the full-length form (translocation into… read more here.
Keywords: chrebp dispensable; energy balance; control glucose; chrebp ... See more keywords
Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci89934
Abstract: Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remain largely unknown. Here, we have presented evidence supporting the… read more here.
Keywords: lipogenic transcription; fructose induced; transcription factor; chrebp ... See more keywords
ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-15
Abstract: Obesity appears to be a major contributing factor for many health problems. Effective treatments for reducing weight gain, other than caloric restriction and exercise, are limited. The consumption of sugars is a major factor in… read more here.
Keywords: high sucrose; sucrose diet; chrebp deficient; expression ... See more keywords
ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.587189
Abstract: Carbohydrate response element-binding protein (ChREBP) plays an important role in the development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well as tumorigenesis. ChREBP is highly expressed in lipogenic organs, such as… read more here.
Keywords: chrebp; lipid metabolism; gut microbiota; adipose tissue ... See more keywords