Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
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DOI: 10.1021/acs.jmedchem.9b00141
Abstract: Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation and mitigation of… read more here.
Keywords: ligand based; nav1 inhibitors; arylsulfonamide nav1; structure ligand ... See more keywords