FET fusion oncoproteins interact with BRD4 and SWI/SNF chromatin remodelling complex subtypes in sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13195
Abstract: FET fusion oncoproteins containing one of the FET (FUS, EWSR1, TAF15) family proteins juxtaposed to alternative transcription‐factor partners are characteristic of more than 20 types of sarcoma and leukaemia. FET oncoproteins bind to the SWI/SNF… read more here.
Keywords: fet oncoproteins; swi snf; fet fusion; chromatin ... See more keywords
Sequence‐specific targeting of chromatin remodelers organizes precisely positioned nucleosomes throughout the genome
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600183
Abstract: Eukaryotic genomes are functionally organized into chromatin, a compact packaging of nucleoproteins with the basic repeating unit known as the nucleosome. A major focus for the chromatin field has been understanding what rules govern nucleosome… read more here.
Keywords: throughout genome; sequence specific; chromatin; positioned nucleosomes ... See more keywords
Chromatin Stability as a Target for Cancer Treatment
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DOI: 10.1002/bies.201800141
Abstract: In this essay, I propose that DNA‐binding anti‐cancer drugs work more via chromatin disruption than DNA damage. Success of long‐awaited drugs targeting cancer‐specific drivers is limited by the heterogeneity of tumors. Therefore, chemotherapy acting via… read more here.
Keywords: dna damage; dna; chromatin; treatment ... See more keywords
Epigenetic editing: Dissecting chromatin function in context
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DOI: 10.1002/bies.202000316
Abstract: How epigenetic mechanisms regulate genome output and response to stimuli is a fundamental question in development and disease. Past decades have made tremendous progress in deciphering the regulatory relationships involved by correlating aggregated (epi)genomics profiles… read more here.
Keywords: chromatin; dissecting chromatin; chromatin function; epigenetic editing ... See more keywords
Can aggressive cancers be identified by the “aggressiveness” of their chromatin?
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DOI: 10.1002/bies.202100212
Abstract: Phenotypic plasticity is a crucial feature of aggressive cancer, providing the means for cancer progression. Stochastic changes in tumor cell transcriptional programs increase the chances of survival under any condition. I hypothesize that unstable chromatin… read more here.
Keywords: aggressive cancers; identified aggressiveness; unstable chromatin; cancers identified ... See more keywords
Non‐canonical bivalent H3K4me3K9me3 recognition by Spindlin1/C11orf84 complex
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DOI: 10.1002/bies.202100229
Abstract: Bivalent chromatin with active H3K4me3 and repressive H3K27me3 was initially identified in embryonic stem cells (ESCs) to poise expression of developmental genes upon lineage commitment. Since then, many more different bivalent modifications have been demonstrated… read more here.
Keywords: spindlin1 c11orf84; non canonical; bivalent; c11orf84 complex ... See more keywords
Genome architecture and totipotency: An intertwined relation during early embryonic development
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DOI: 10.1002/bies.202200029
Abstract: Chromosomes are not randomly packed and positioned into the nucleus but folded in higher‐order chromatin structures with defined functions. However, the genome of a fertilized embryo undergoes a dramatic epigenetic reprogramming characterized by extensive chromatin… read more here.
Keywords: development; architecture; chromatin; architecture totipotency ... See more keywords
Removal of chromatin by salt-tolerant endonucleases for production of recombinant measles virus.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3342
Abstract: Host cell DNA is a critical impurity in downstream processing of enveloped viruses. Especially, DNA in the form of chromatin is often neglected. Endonuclease treatment is an almost mandatory step in manufacturing of viral vaccines.… read more here.
Keywords: tolerant endonucleases; measles virus; salt tolerant; recombinant measles ... See more keywords
A guide for single-particle chromatin tracking in live cell nuclei.
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DOI: 10.1002/cbin.11762
Abstract: The emergence of labeling strategies and live cell imaging methods enables the imaging of chromatin in living cells at single digit nanometer resolution as well as milliseconds temporal resolution. These technical breakthroughs revolutionize our understanding… read more here.
Keywords: chromatin; guide single; particle chromatin; single particle ... See more keywords
Nuclear cytometry and chromatin organization
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DOI: 10.1002/cyto.a.23521
Abstract: The nuclear‐targeting chemical probe, for the detection and quantification of DNA within cells, has been a mainstay of cytometry—from the colorimetric Feulgen stain to smart fluorescent agents with tuned functionality. The level of nuclear structure… read more here.
Keywords: nuclear cytometry; dna; chromatin; chromatin organization ... See more keywords
Chromatin remodelers in oligodendroglia
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DOI: 10.1002/glia.23837
Abstract: Oligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which… read more here.
Keywords: remodelers oligodendroglia; chromatin; chromatin remodelers; chromatin remodeling ... See more keywords