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   Articles with "chromatin accessibility" as a keyword



Chromatin Accessibility Plays an Important Epigenetic Role on Antibody Expression From CMV Promoter and DNA Elements Flanking the CHO TI Host Landing‐Pad

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recommendations! Published in 2024 at "Biotechnology Journal"

DOI: 10.1002/biot.202400487

Abstract: Targeted integration (TI) Chinese hamster ovary (CHO) platforms are commonly used for protein expression. However, the impact of epigenetic modifications on protein expression in TI cell lines remains elusive since almost all the epigenetic studies… read more here.

Keywords: expression; chromatin accessibility; cmv; cho ... See more keywords

Comprehensive analysis of nonsurrounded nucleolus and surrounded nucleolus oocytes on chromatin accessibility using ATAC‐seq

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recommendations! Published in 2023 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23668

Abstract: Mouse germinal vesicle (GV) oocytes are divided into surrounded nucleolus (SN) and nonsurrounded nucleolus (NSN) oocytes based on chromatin morphology. NSN oocytes spontaneously transform into SN oocytes after accumulating enough maternal transcripts. SN oocytes show… read more here.

Keywords: nsn oocytes; surrounded nucleolus; accessibility; nonsurrounded nucleolus ... See more keywords

Single-Molecule Multikilobase-Scale Profiling of Chromatin Accessibility Using m6A-SMAC-Seq and m6A-CpG-GpC-SMAC-Seq.

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recommendations! Published in 2022 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-2140-0_15

Abstract: A hallmark feature of active cis-regulatory elements (CREs) in eukaryotes is their nucleosomal depletion and, accordingly, higher accessibility to enzymatic treatment. This property has been the basis of a number of sequencing-based assays for genome-wide… read more here.

Keywords: chromatin accessibility; smac seq; single molecule; seq ... See more keywords
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Heat stress causes chromatin accessibility and related gene expression changes in crown tissues of barley (Hordeum vulgare)

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recommendations! Published in 2024 at "Plant Molecular Biology"

DOI: 10.1007/s11103-024-01509-x

Abstract: Plant responses to stress caused by high temperatures involve changes occurring at the molecular, metabolic, and physiological levels. Understanding the mechanisms by which plants recognize signals to activate this response is a prerequisite for identifying… read more here.

Keywords: gene expression; chromatin accessibility; gene; heat ... See more keywords

Tissue-Specific Chromatin Accessibility Regions and Transcription Factor Binding Sites in Pig Brain and Endocrine Tissues

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recommendations! Published in 2025 at "Molecular Neurobiology"

DOI: 10.1007/s12035-025-05128-5

Abstract: The cognitive and regulatory processes within higher-order brain structures that regulate the hypothalamic–pituitary–adrenal (HPA) axis and the limbic system orchestrate a complex stress response system. In order to address this, we collected 48 tissue samples… read more here.

Keywords: endocrine tissues; brain; chromatin accessibility; chromatin ... See more keywords

373P Chromatin accessibility reveals potential prognostic value of the peak set associated with smoking history in patients with lung adenocarcinoma

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recommendations! Published in 2020 at "Annals of Oncology"

DOI: 10.1016/j.annonc.2020.10.366

Abstract: K. Prabhash, A.R. Jazieh, H.C. Onal, D.S. Weng Tan, R.A. Soo, A. Kumar, R. Huggenberger, S. Robb, B.C. Cho Medical Onclogy Department, Tata Memorial Hospital, Mumbai, India; Department of Oncology, King Abdullah International Medical Research… read more here.

Keywords: accessibility reveals; potential prognostic; 373p chromatin; chromatin accessibility ... See more keywords

Chromatin Accessibility Studied by Slow Scan FCS in the Eukaryotic Nucleus

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1195

Abstract: DNA is one of the most important biological macromolecules, since it harbors the genetic information of the cell. In order to fit in eukaryotic cell nucleus, DNA is highly compacted and packed by histones in… read more here.

Keywords: accessibility; slow scan; chromatin accessibility; cell ... See more keywords
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HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.06.008

Abstract: In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals… read more here.

Keywords: finally open; hdac inhibitors; accessibility; open chromatin ... See more keywords

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin

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recommendations! Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2020.09.056

Abstract: Cell differentiation and function are regulated across multiple layers of gene regulation, including modulation of gene expression by changes in chromatin accessibility. However, differentiation is an asynchronous process precluding a temporal understanding of regulatory events… read more here.

Keywords: single cell; chromatin; chromatin accessibility; chromatin potential ... See more keywords

Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.108180

Abstract: SUMMARY Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive. Here, we analyze global chromatin accessibility profiles across resting and stimulated human… read more here.

Keywords: chromatin; heterogeneity; chromatin landscape; chromatin accessibility ... See more keywords

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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recommendations! Published in 2021 at "Immunity"

DOI: 10.1016/j.immuni.2021.03.007

Abstract: Summary Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine… read more here.

Keywords: single cell; treg cells; tissue; chromatin accessibility ... See more keywords