Chromatin Architecture Emerges during Zygotic Genome Activation Independent of Transcription
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.024
Abstract: Chromatin architecture is fundamental in regulating gene expression. To investigate when spatial genome organization is first established during development, we examined chromatin conformation during Drosophila embryogenesis and observed the emergence of chromatin architecture within a tight… read more here.
Keywords: transcription; zygotic genome; chromatin architecture; activation ... See more keywords
tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108206
Abstract: Spatiotemporal chromatin reorganization during hematopoietic differentiation has not been comprehensively characterized, mainly because of the large numbers of starting cells required for current chromatin conformation capture approaches. Here, we introduce a low-input tagmentation-based Hi-C (tagHi-C)… read more here.
Keywords: taghi; chromatin; reveals chromatin; chromatin architecture ... See more keywords
Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.019
Abstract: Chromatin organization undergoes drastic reconfiguration during gametogenesis. However, the molecular reprogramming of three-dimensional chromatin structure in this process remains poorly understood for mammals, including primates. Here, we examined three-dimensional chromatin architecture during spermatogenesis in rhesus… read more here.
Keywords: meiotic chromatin; chromatin; chromatin architecture; architecture spermatogenesis ... See more keywords
Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27800-9
Abstract: Folliculogenesis is a complex biological process involving a central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture is an important transcription regulator; however, little is known about its dynamics and role in transcriptional regulation… read more here.
Keywords: chromatin architecture; granulosa cells; cells chicken;
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Genetics"
DOI: 10.1038/s41588-019-0457-0
Abstract: Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined… read more here.
Keywords: three dimensional; genetics; islet; human pancreatic ... See more keywords
Joint profiling of DNA methylation and chromatin architecture in single cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature methods"
DOI: 10.1038/s41592-019-0502-z
Abstract: We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in… read more here.
Keywords: chromatin; dna methylation; chromatin architecture; single cells ... See more keywords
Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220889
Abstract: The disruption of chromatin-regulating genes is associated with many neurocognitive syndromes. While most of these genes are ubiquitously expressed across various cell-types, many chromatin regulators act upon activity regulated genes (ARGs) that play central roles… read more here.
Keywords: modulation chromatin; activity regulated; chromatin architecture; expression ... See more keywords
Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1814965116
Abstract: Significance Chromatin dynamics play a central role in the DNA damage response (DDR). A longstanding experimental obstacle was the lack of technology capable of visualizing chromatin dynamics at double-strand break (DSB) sites. Here, we describe… read more here.
Keywords: dna damage; damage response; microscopy; chromatin ... See more keywords
Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erac517
Abstract: Abstract Emerging evidence reveals that the three-dimensional (3D) chromatin architecture plays a key regulatory role in various biological processes of plants. However, information on the 3D chromatin architecture of the legume model plant Medicago truncatula… read more here.
Keywords: truncatula; three dimensional; deficiency; chromatin architecture ... See more keywords
Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab053
Abstract: Abstract The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is… read more here.
Keywords: negative breast; fra; family; breast cancers ... See more keywords
Abstract 1006: Non-linear relationship between estradiol-regulated changes in chromatin architecture and gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1158/1538-7445.am2019-1006
Abstract: Gene expression in estrogen receptor (ER)-positive breast cancer cells is predominantly driven by ER-estradiol (E2) signaling. However, the effects of ER-E2 signaling on the overall chromatin architecture and accessibility to transcription regulators are not well… read more here.
Keywords: gene; chromatin; gene expression; chromatin architecture ... See more keywords