Yeast Nucleoplasmic Extracts and an Application to Visualize Chromatin Assembly on Single Molecules of DNA.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0868-5_15
Abstract: In eukaryotic cells, the genomic DNA is packaged into chromatin, the basic unit of which is the nucleosome. Studying the mechanism of chromatin formation under physiological conditions is inherently difficult due to the limitations of… read more here.
Keywords: chromatin assembly; extracts application; chromatin; nucleoplasmic extracts ... See more keywords
Histones H3 and H4 require their relevant amino-tails for efficient nuclear import and replication-coupled chromatin assembly in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03218-6
Abstract: Concomitant chromatin assembly and DNA duplication is essential for cell survival and genome integrity, and requires newly synthesized histones. Although the N-terminal domains of newly synthesized H3 and H4 present critical functions, their requirement for… read more here.
Keywords: chromatin; coupled chromatin; chromatin assembly; replication coupled ... See more keywords
Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.
Sign Up to like & getrecommendations! Published in 2023 at "Blood advances"
DOI: 10.1182/bloodadvances.2022009438
Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer that stems from the rapid expansion of immature leukemic blasts in the bone marrow. Mutations in epigenetic factors represent the largest category of genetic drivers of… read more here.
Keywords: aml; repression; chromatin assembly; factor chaf1b ... See more keywords
PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.220970
Abstract: ABSTRACT The incorporation of the histone H3 variant, H3.3, into chromatin by the H3.3-specific chaperone DAXX and the ATP-dependent chromatin remodeling factor ATRX is a critical mechanism for silencing repetitive DNA. DAXX and ATRX are… read more here.
Keywords: chromatin assembly; chromatin; pml recruited; daxx mediated ... See more keywords