A shift in chromatin binding of phosphorylated p38 precedes transcriptional changes upon oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.15006
Abstract: P38 mitogen‐activated protein kinases are key in the regulation of the cellular response to stressors. P38 is known to regulate transcription, mRNA processing, stability, and translation. The transcriptional changes mediated by phosphorylated p38 (P‐p38) in… read more here.
Keywords: phosphorylated p38; transcriptional changes; chromatin; oxidative stress ... See more keywords
Tracing Reversible Light-Induced Chromatin Binding with Near-infrared Fluorescent Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0755-8_12
Abstract: Blue light-induced chromatin recruitment (BLInCR) is a versatile optogenetic tool to enrich effector proteins at specific loci within the nucleus using illumination in the 400-500 nm range. The resulting chromatin binding reaction is reversible on the… read more here.
Keywords: light induced; near infrared; fluorescent; light ... See more keywords
Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94715-2
Abstract: Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade. It has been shown that forkhead box P3 protein is a TFPI transcriptional repressor. However, there… read more here.
Keywords: mrna levels; drug; binding regulatory; chromatin binding ... See more keywords
WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantation.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2504361122
Abstract: Significance Uterine receptivity is a prerequisite for successful embryo implantation. Progesterone receptor (PR)-mediated progesterone (P4) signaling is indispensable for conferring uterine receptivity. However, the mechanisms underlying PR–chromatin binding remain ambiguous. Here, we identified transcription factor… read more here.
Keywords: essential uterine; progesterone receptor; receptivity; chromatin binding ... See more keywords
Interplay of condensation and chromatin binding underlies BRD4 targeting
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology of the Cell"
DOI: 10.1101/2024.02.07.579384
Abstract: Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific chromatin regions, including transcriptional initiation condensates, which are composed of transcription factors and… read more here.
Keywords: condensation; chromatin; interplay condensation; chromatin binding ... See more keywords
CXXC1 is required for IRF4 chromatin binding and expression and regulates cellular fitness in lenalidomide-sensitive and -resistant myeloma cells
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-571
Abstract: IRF4 is a plasma cell lineage-defining transcription factor that orchestrates important aspects of the oncogenic transcriptome in multiple myeloma (MM) largely through the deregulated IKZF1/3-IRF4-MYC axis. This transcription factor feed-forward loop is also critical for… read more here.
Keywords: myeloma cells; cxxc1; irf4; chromatin binding ... See more keywords
Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007117
Abstract: The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral… read more here.
Keywords: p12; p12 tethers; integration; chromatin ... See more keywords