Sperm chromatin condensation defects, but neither DNA fragmentation nor aneuploidy, are an independent predictor of clinical pregnancy after intracytoplasmic sperm injection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-019-01471-4
Abstract: PurposeThe impact of sperm DNA damage on intracytoplasmic sperm injection (ICSI) outcomes remains controversial. The purpose of the study was to evaluate the prognostic value of several types of sperm nuclear damage on ICSI clinical… read more here.
Keywords: pregnancy; dna fragmentation; clinical pregnancy; condensation defects ... See more keywords
Label-Free Evaluation of Chromatin Condensation in Human Normal Morphology Sperm Using Raman Spectroscopy
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00494-6
Abstract: Chromatin condensation is one of the main factors essential for sperm function. Evaluation of chromatin condensation by current methods render the assessed sperm unsuitable for assisted reproduction. We examined the Raman spectra of normal morphology… read more here.
Keywords: morphology sperm; normal morphology; spectroscopy; chromatin condensation ... See more keywords
Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100740
Abstract: A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles, amphibians, and birds, undergo nuclear condensation but do not enucleate. Enucleation… read more here.
Keywords: terminal erythropoiesis; condensation; maturation; enucleation ... See more keywords
Chromatin condensation regulates endothelial cell adaptation to shear stress
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0064
Abstract: Vascular endothelial cells (ECs) have been shown to be mechanoresponsive to the forces of blood flow, including fluid shear stress (FSS), the frictional force of blood on the vessel wall. Recent reports have shown that… read more here.
Keywords: shear stress; condensation; adaptation; chromatin condensation ... See more keywords
Sensitive effect of linker histone binding mode and subtype on chromatin condensation
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz234
Abstract: Abstract The complex role of linker histone (LH) on chromatin compaction regulation has been highlighted by recent discoveries of the effect of LH binding variability and isoforms on genome structure and function. Here we examine… read more here.
Keywords: chromatin; effect; linker histone; binding mode ... See more keywords
Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.709923
Abstract: Vertebrate erythropoiesis involves nuclear and chromatin condensation at the early stages of terminal differentiation, which is a unique process to distinguish mature erythrocytes from erythroblasts. However, the underlying mechanisms of chromatin condensation during erythrocyte maturation… read more here.
Keywords: erythroid maturation; tpr; maturation; deficiency ... See more keywords
Oxidative Stress Is Associated with Telomere Interaction Impairment and Chromatin Condensation Defects in Spermatozoa of Infertile Males
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DOI: 10.3390/antiox10040593
Abstract: Telomere length can be influenced by reactive oxygen species (ROS) generated by lifestyle factors or environmental exposure. We sought to determine whether oxidative stress has an impact on sperm nuclear alterations, especially on chromatin organization… read more here.
Keywords: oxidative stress; condensation defects; infertile males; chromatin condensation ... See more keywords
Sperm Chromatin Condensation Defect Accelerates the Kinetics of Early Embryonic Development but Does Not Modify ICSI Outcome
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010393
Abstract: The origin and quality of gametes are likely to influence the kinetics of embryonic development. The purpose of the study was to assess the impact of sperm nuclear quality, and in particular sperm chromatin condensation,… read more here.
Keywords: embryonic development; condensation; sperm chromatin; chromatin condensation ... See more keywords