Straightforward protocol for allele-specific chromatin conformation capture.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145185
Abstract: A key advance in our understanding of gene regulation came with the finding that the genome undergoes three-dimensional nuclear folding in a genetically determined process. This 3D conformation directly influences the association between enhancers and… read more here.
Keywords: chromatin; specific chromatin; conformation; allele specific ... See more keywords
Chromatin conformation analysis of primary patient tissue using a low input Hi-C method
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06961-0
Abstract: Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation. However, our ability to examine its biological function and role in disease is limited by the large amounts of starting material required to perform current… read more here.
Keywords: method; tissue; conformation; chromatin conformation ... See more keywords
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00842-x
Abstract: In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is affected by these… read more here.
Keywords: dynamics modulates; expression; allele specific; chromatin conformation ... See more keywords
Conservation of chromatin conformation in carnivores
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120555119
Abstract: Significance We found the three-dimensional (3D) structure of chromatin at the chromosome level to be highly conserved for more than 50 million y of carnivore evolution. Intrachromosomal contacts were maintained even after chromosome rearrangements within… read more here.
Keywords: chromatin conformation; dna; conservation chromatin; chromatin ... See more keywords
Chromatin Conformation Links Distal Target Genes to CKD Loci.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016080875
Abstract: Genome-wide association studies (GWASs) have identified many genetic risk factors for CKD. However, linking common variants to genes that are causal for CKD etiology remains challenging. By adapting self-transcribing active regulatory region sequencing, we evaluated… read more here.
Keywords: target genes; target; ckd associated; conformation links ... See more keywords