Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.017
Abstract: Lamins are structural components of the nuclear lamina (NL) that regulate genome organization and gene expression, but the mechanism remains unclear. Using Hi-C, we show that lamins maintain proper interactions among the topologically associated chromatin… read more here.
Keywords: nuclear periphery; chromatin domains; genome; lamins organize ... See more keywords
On the existence and functionality of topologically associating domains
Sign Up to like & getrecommendations! Published in 2020 at "Nature Genetics"
DOI: 10.1038/s41588-019-0561-1
Abstract: Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin domains. Topologically associating domains (TADs) were originally discovered empirically in low-resolution Hi-C heat maps representing ensemble average interaction frequencies from millions of cells.… read more here.
Keywords: chromatin domains; associating domains; functionality topologically; existence functionality ... See more keywords
The multiscale effects of polycomb mechanisms on 3D chromatin folding
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2019.1679082
Abstract: Abstract Polycomb group (PcG) proteins silence master regulatory genes required to properly confer cell identity during the development of both Drosophila and mammals. They may act through chromatin compaction and higher-order folding of chromatin inside… read more here.
Keywords: chromatin domains; chromatin folding; chromatin; pcg proteins ... See more keywords
Fast detection of differential chromatin domains with SCIDDO
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa960
Abstract: Abstract Motivation The generation of genome-wide maps of histone modifications using chromatin immunoprecipitation sequencing is a standard approach to dissect the complexity of the epigenome. Interpretation and differential analysis of histone datasets remains challenging due… read more here.
Keywords: chromatin domains; chromatin; analysis; differential chromatin ... See more keywords
Formation of correlated chromatin domains at nanoscale dynamic resolution during transcription
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky269
Abstract: Abstract Intrinsic dynamics of chromatin contribute to gene regulation. How chromatin mobility responds to genomic processes, and whether this response relies on coordinated chromatin movement is still unclear. Here, we introduce an approach called Dense… read more here.
Keywords: chromatin domains; formation correlated; chromatin; time ... See more keywords
Genetic Organization of Open Chromatin Domains Situated in Polytene Chromosome Interbands in Drosophila
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672918060078
Abstract: New data on the organization of genes entirely located in the open domains for chromatin transcription and occupying only one chromosome structure (interband) were obtained. The characteristic features of these genes are the small size… read more here.
Keywords: chromatin domains; organization open; genetic organization; open chromatin ... See more keywords