Probing Chromatin Structure with Magnetic Tweezers.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8591-3_18
Abstract: Magnetic tweezers form a unique tool to study the topology and mechanical properties of chromatin fibers. Chromatin is a complex of DNA and proteins that folds the DNA in such a way that meter-long stretches… read more here.
Keywords: chromatin; chromatin fibers; spectroscopy; structure ... See more keywords
Linking Chromatin Fibers to Gene Folding by Hierarchical Looping.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.01.003
Abstract: While much is known about DNA structure on the basepair level, this scale represents only a fraction of the structural levels involved in folding the genomic material. With recent advances in experimental and theoretical techniques,… read more here.
Keywords: hierarchical looping; chromatin; chromatin fibers; level ... See more keywords
Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02619-5
Abstract: The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster resonance energy transfer studies to reveal structural states and their interconversion kinetics in chromatin… read more here.
Keywords: single molecule; chromatin; chromatin fibers; fret reveals ... See more keywords
A critical role for linker DNA in higher-order folding of chromatin fibers
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab058
Abstract: Abstract Nucleosome-nucleosome interactions drive the folding of nucleosomal arrays into dense chromatin fibers. A better physical account of the folding of chromatin fibers is necessary to understand the role of chromatin in regulating DNA transactions.… read more here.
Keywords: dna; chromatin; chromatin fibers; linker dna ... See more keywords
Structure and Epigenetic Regulation of Chromatin Fibers.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2017.82.033795
Abstract: In eukaryotes, genomic DNA is hierarchically packaged by histones into chromatin on several levels to fit inside the nucleus. As a central-level structure between nucleosomal arrays and higher-order chromatin organizations, the 30-nm chromatin fiber and… read more here.
Keywords: regulation chromatin; chromatin; chromatin fibers; biology ... See more keywords