Interrogating the Accessible Chromatin Landscape of Eukaryote Genomes Using ATAC-seq.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1103-6_10
Abstract: The ATAC-seq assay has emerged as the most useful, versatile, and widely adaptable method for profiling accessible chromatin regions and tracking the activity of cis-regulatory elements (cREs) in eukaryotes. Thanks to its great utility, it… read more here.
Keywords: accessible chromatin; atac seq; chromatin; interrogating accessible ... See more keywords
Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108180
Abstract: SUMMARY Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive. Here, we analyze global chromatin accessibility profiles across resting and stimulated human… read more here.
Keywords: chromatin; heterogeneity; chromatin landscape; chromatin accessibility ... See more keywords
Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109625
Abstract: SUMMARY The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we profile the chromatin landscape and AR-directed transcriptional program in normal prostate cells and show the impact… read more here.
Keywords: prostate; prostate cells; androgen; normal prostate ... See more keywords
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.05.022
Abstract: Disruptive mutations in chromatin remodeler CHD8 cause autism spectrum disorders, exhibiting widespread white matter abnormalities; however, the underlying mechanisms remain elusive. We show that cell-type specific Chd8 deletion in oligodendrocyte progenitors, but not in neurons,… read more here.
Keywords: histone methyltransferase; chromatin landscape; chd8; myelination ... See more keywords
Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Cell Biology"
DOI: 10.1038/s41556-021-00774-y
Abstract: Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated… read more here.
Keywords: neutrophilia inflammation; chromatin landscape; chaperone daxx; daxx haematopoietic ... See more keywords
Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06859-9
Abstract: Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate decisions during placenta development remain ill defined. Here we exploited ATAC-seq and transcriptional… read more here.
Keywords: chromatin; gene expression; chromatin landscape; landscape blimp1 ... See more keywords
Evolution of the Drosophila melanogaster Chromatin Landscape and Its Associated Proteins
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz019
Abstract: Abstract In the nucleus of eukaryotic cells, genomic DNA associates with numerous protein complexes and RNAs, forming the chromatin landscape. Through a genome-wide study of chromatin-associated proteins in Drosophila cells, five major chromatin types were… read more here.
Keywords: chromatin; associated proteins; drosophila melanogaster; chromatin landscape ... See more keywords
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abf8705
Abstract: Chromatin landscape dictates remodeling Large, multicomponent molecular machines known as mammalian SWI/SNF (mSWI/SNF) chromatin-remodeling complexes play critical roles in governing the architecture of our genomes. These entities bind to chromatin (DNA assembled on proteins) inside… read more here.
Keywords: landscape signals; chromatin; mswi snf; chromatin landscape ... See more keywords
PO-305 Chromatin accessibility profiling identifies an underlying HNF4A-GATA6 regulatory module in oesophageal adenocarcinoma
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DOI: 10.1136/esmoopen-2018-eacr25.335
Abstract: Introduction The chromatin landscape of mammalian cells underpins their transcriptional profiles, which then dictate fate and function. Mutations within chromatin remodelling genes have been implicated in early oesophageal adenocarcinoma (OAC) development, thus alterations in the… read more here.
Keywords: chromatin; hnf4a gata6; chromatin landscape; oesophageal ... See more keywords
Abstract P6-04-24: Transcription factor dynamics in endocrine therapy resistance models using a novel chromatin landscape analysis algorithm based on ATAC-Seq
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p6-04-24
Abstract: Endocrine therapy resistance is one of the major challenges in breast cancer therapy today. As the causes are not well understood, therapeutic options are limited. To investigate the molecular mechanisms of endocrine therapy resistance, we… read more here.
Keywords: transcription; resistance; therapy resistance; endocrine therapy ... See more keywords
Stress as a Chromatin Landscape Architect
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.790138
Abstract: The exponential development of methods investigating different levels of spatial genome organization leads to the appreciation of the chromatin landscape's contribution to gene regulation and cell fate. Multiple levels of 3D chromatin organization include chromatin… read more here.
Keywords: landscape; chromatin landscape; landscape architect; stress chromatin ... See more keywords