The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.013
Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can… read more here.
Keywords: chromatin loop; cohesin; factor wapl; release factor ... See more keywords
Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45386-w
Abstract: Although emerging evidence indicates that alterations in proteins within nuclear compartments elicit changes in chromosomal architecture and differentiation, the underlying mechanisms are not well understood. Here we investigate the direct role of the abundant nuclear… read more here.
Keywords: mediated enhancer; chromatin loop; yy1 mediated; chromatin ... See more keywords
Be-1DCNN: a neural network model for chromatin loop prediction based on bagging ensemble learning.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elad015
Abstract: The chromatin loops in the three-dimensional (3D) structure of chromosomes are essential for the regulation of gene expression. Despite the fact that high-throughput chromatin capture techniques can identify the 3D structure of chromosomes, chromatin loop… read more here.
Keywords: neural network; chromatin loop; chromatin loops; prediction ... See more keywords
The rice AT-rich pincer-like element family of conserved noncoding sequences regulates chromatin loop formation.
Sign Up to like & getrecommendations! Published in 2025 at "Plant physiology"
DOI: 10.1093/plphys/kiaf211
Abstract: The comprehensive annotation of regulatory elements in linear genomes is needed to elucidate the molecular mechanisms underlying chromatin loop formation in plants. Here, we characterized a novel family of conserved noncoding sequences (CNSs) in the… read more here.
Keywords: loop formation; rich pincer; chromatin loop; conserved noncoding ... See more keywords
3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.04.15.488456
Abstract: Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo. Polymer physics-based modeling of chromosome structure has been instrumental to assess… read more here.
Keywords: simulation framework; chromatin loop; loop extrusion;
Chromatin Loop Formation Induced by a Subtelomeric Protosilencer Represses EPA Genes in Candida glabrata
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301202
Abstract: Adherence, an important virulence factor, is mediated by the EPA (Epithelial Adhesin) genes in the opportunistic pathogen Candida glabrata. Expression of adhesin-encoding genes requires tight regulation to respond to harsh environmental conditions within the host.… read more here.
Keywords: chromatin loop; epa3; formation; protosilencer ... See more keywords