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Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.013
Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can…
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Keywords:
chromatin loop;
cohesin;
factor wapl;
release factor ... See more keywords
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2
Published in 2023 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elad015
Abstract: The chromatin loops in the three-dimensional (3D) structure of chromosomes are essential for the regulation of gene expression. Despite the fact that high-throughput chromatin capture techniques can identify the 3D structure of chromosomes, chromatin loop…
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Keywords:
neural network;
chromatin loop;
chromatin loops;
prediction ... See more keywords
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Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.04.15.488456
Abstract: Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo. Polymer physics-based modeling of chromosome structure has been instrumental to assess…
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Keywords:
simulation framework;
chromatin loop;
loop extrusion;
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Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301202
Abstract: Adherence, an important virulence factor, is mediated by the EPA (Epithelial Adhesin) genes in the opportunistic pathogen Candida glabrata. Expression of adhesin-encoding genes requires tight regulation to respond to harsh environmental conditions within the host.…
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Keywords:
chromatin loop;
epa3;
formation;
protosilencer ... See more keywords