MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
Sign Up to like & getrecommendations! Published in 2017 at "Nature immunology"
DOI: 10.1038/ni.3812
Abstract: MLL4 is an essential subunit of the histone H3 Lys4 (H3K4)-methylation complexes. We found that MLL4 deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4… read more here.
Keywords: via chromatin; chromatin; chromatin looping; mll4 ... See more keywords
Three-dimensional Epigenome Statistical Model: Genome-wide Chromatin Looping Prediction
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23276-8
Abstract: This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcription… read more here.
Keywords: three dimensional; dimensional epigenome; transcription; chromatin ... See more keywords
HiCORE: Hi-C Analysis for Identification of Core Chromatin Looping Regions with Higher Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Molecules and cells"
DOI: 10.14348/molcells.2021.0145
Abstract: Genome-wide chromosome conformation capture (3C)- based high-throughput sequencing (Hi-C) has enabled identification of genome-wide chromatin loops. Because the Hi-C map with restriction fragment resolution is intrinsically associated with sparsity and stochastic noise, Hi-C data are… read more here.
Keywords: chromatin looping; regions higher; chromatin; looping regions ... See more keywords
ZNF143 in Chromatin Looping and Gene Regulation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00338
Abstract: ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression… read more here.
Keywords: chromatin; chromatin looping; znf143; factor ... See more keywords
Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.901747
Abstract: The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in complex autoimmune… read more here.
Keywords: chromatin looping; rca gene; rca; gene ... See more keywords