Metabolic intermediates – Cellular messengers talking to chromatin modifiers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.007
Abstract: Background To maintain homeostasis, cells need to coordinate the expression of their genes. Epigenetic mechanisms controlling transcription activation and repression include DNA methylation and post-translational modifications of histones, which can affect the architecture of chromatin… read more here.
Keywords: intermediates cellular; chromatin; metabolic intermediates; modifying enzymes ... See more keywords
Chromatin-modifying elements for recombinant protein production in mammalian cell systems
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2020.1805401
Abstract: Abstract Mammalian cells are the preferred choice system for the production of complex molecules, such as recombinant therapeutic proteins. Although the technology for increasing the yield of proteins has improved rapidly, the process of selecting,… read more here.
Keywords: production; modifying elements; chromatin modifying; expression ... See more keywords
JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1134268
Abstract: The multisubunit NuA4/TIP60 complex is a lysine acetyltransferase, chromatin modifying factor and gene co-activator involved in diverse biological processes. The past decade has seen a growing appreciation for its role as a metabolic effector and… read more here.
Keywords: subunit; jazf1 metabolic; nua4 tip60; chromatin modifying ... See more keywords
Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1183871
Abstract: Background Idiopathic Pulmonary Fibrosis (IPF) can be described as a debilitating lung disease that is characterized by the complex interactions between various immune cell types and signaling pathways. Chromatin-modifying enzymes are significantly involved in regulating… read more here.
Keywords: ipf; chromatin modifying; idiopathic pulmonary; expression ... See more keywords