Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2017.05.004
Abstract: Ubiquitous Chromatin-opening Elements (UCOEs) are defined by their ability to consistently confer stable, site of integration-independent transgene expression that is proportional to copy number, including from within regions of heterochromatin such as centromeres. UCOEs structurally… read more here.
Keywords: opening elements; ubiquitous chromatin; chromatin opening; gene ... See more keywords
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
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DOI: 10.1038/s41467-019-11054-7
Abstract: Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns and transcriptional waves with Oct6… read more here.
Keywords: pluripotency; oct4 sox2; chromatin opening; pluripotency reprogramming ... See more keywords
The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function
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DOI: 10.1038/s41598-017-04212-8
Abstract: Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny. Transgene expression in these cells,… read more here.
Keywords: cpg sites; ubiquitous chromatin; anti silencing; chromatin opening ... See more keywords