Nuclear cytometry and chromatin organization
Sign Up to like & getrecommendations! Published in 2018 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23521
Abstract: The nuclear‐targeting chemical probe, for the detection and quantification of DNA within cells, has been a mainstay of cytometry—from the colorimetric Feulgen stain to smart fluorescent agents with tuned functionality. The level of nuclear structure… read more here.
Keywords: nuclear cytometry; dna; chromatin; chromatin organization ... See more keywords
Fluid-like chromatin: Toward understanding the real chromatin organization present in the cell.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.02.016
Abstract: Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on the surrounding environment (i.e. cations… read more here.
Keywords: chromatin; chromatin organization; cell; fluid like ... See more keywords
Influence of Chromatin 3D Organization on Structural Variations of the Arabidopsis thaliana Genome.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular plant"
DOI: 10.1016/j.molp.2016.09.015
Abstract: The spectrum of genetic variations ranges from single nucleotide polymorphisms (SNPs) to large-scale structural variants (SVs). Genome SVs involving kilobase- to megabase-sized insertions, deletions, duplications, and inversions, as well as complex combinations of rearrangements, are… read more here.
Keywords: structural variations; arabidopsis thaliana; organization structural; variations arabidopsis ... See more keywords
Nanoscale Chromatin Imaging and Analysis (nano-ChIA) Platform Bridges 4-D Chromatin Organization with Molecular Function
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620016785
Abstract: The dynamic, three-dimensional chromatin organization plays an important role in regulating a vast number of cellular processes, including cell-type-specific gene expression and lineage commitment (1-3). Large-scale alterations in chromatin structure are associated with cancer, numerous… read more here.
Keywords: nanoscale chromatin; chromatin; chromatin imaging; chromatin organization ... See more keywords
Two independent modes of chromatin organization revealed by cohesin removal
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24281
Abstract: Imaging and chromosome conformation capture studies have revealed several layers of chromosome organization, including segregation into megabase-sized active and inactive compartments, and partitioning into sub-megabase domains (TADs). It remains unclear, however, how these layers of… read more here.
Keywords: independent modes; modes chromatin; organization revealed; two independent ... See more keywords
Bioinformatic analysis of chromatin organization and biased expression of duplicated genes between two poplars with a common whole-genome duplication
Sign Up to like & getrecommendations! Published in 2021 at "Horticulture Research"
DOI: 10.1038/s41438-021-00494-2
Abstract: The nonrandom three-dimensional organization of chromatin plays an important role in the regulation of gene expression. However, it remains unclear whether this organization is conserved and whether it is involved in regulating gene expression during… read more here.
Keywords: chromatin; chromatin organization; expression; gene expression ... See more keywords
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-20987-x
Abstract: Lamins and transmembrane proteins within the nuclear envelope regulate nuclear structure and chromatin organization. Nuclear envelope transmembrane protein 39 (Net39) is a muscle nuclear envelope protein whose functions in vivo have not been explored. We show… read more here.
Keywords: nuclear envelope; muscle; chromatin organization; envelope ... See more keywords
Connecting high-resolution 3D chromatin organization with epigenomics.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29695-6
Abstract: The resolution of chromatin conformation capture technologies keeps increasing, and the recent nucleosome resolution chromatin contact maps allow us to explore how fine-scale 3D chromatin organization is related to epigenomic states in human cells. Using… read more here.
Keywords: resolution; chromatin; high resolution; resolution chromatin ... See more keywords
Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning
Sign Up to like & getrecommendations! Published in 2021 at "Nature Genetics"
DOI: 10.1038/s41588-021-00799-x
Abstract: The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a relatively… read more here.
Keywords: chromatin; gene; chromatin organization; gene expression ... See more keywords
Theory of chromatin organization maintained by active loop extrusion.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2222078120
Abstract: The active loop extrusion hypothesis proposes that chromatin threads through the cohesin protein complex into progressively larger loops until reaching specific boundary elements. We build upon this hypothesis and develop an analytical theory for active… read more here.
Keywords: loop extrusion; chromatin organization; active loop;
Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz123
Abstract: Abstract In most cells, transcriptionally inactive heterochromatin is preferentially localized in the nuclear periphery and transcriptionally active euchromatin is localized in the nuclear interior. Different cell types display characteristic chromatin distribution patterns, which change dramatically… read more here.
Keywords: heterochromatin; live cells; nuclear membrane; inner nuclear ... See more keywords