Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.028
Abstract: Homeostatic synaptic downscaling reduces neuronal excitability by modulating the number of postsynaptic receptors. Histone modifications and the subsequent chromatin remodeling play critical roles in activity-dependent gene expression. Histone modification codes are recognized by chromatin readers… read more here.
Keywords: chromatin; chromatin reader; activity; l3mbtl1 ... See more keywords
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.08.042
Abstract: Summary Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector component of antibody responses. CSR is initiated by activation-induced cytidine deaminase (AID), which targets transcriptionally active immunoglobulin heavy chain (Igh) switch… read more here.
Keywords: switch; chromatin reader; class switch; zmynd8 ... See more keywords
Depsipeptide Aspergillicins Revealed by Chromatin Reader Protein Deletion.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00161
Abstract: Expression of biosynthetic gene clusters (BGCs) in filamentous fungi is highly regulated by epigenetic remodeling of chromatin structure. Two classes of histone modifying proteins, writers (which place modifications on histone tails) and erasers (which remove… read more here.
Keywords: revealed chromatin; reader; chromatin reader; deletion ... See more keywords
Abstract 4754: Investigating the impact of hotspot mutations in a chromatin reader on leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4754
Abstract: Acute myeloid leukemia (AML) is one of the most aggressive forms of hematological malignancies with a low overall 5-year survival rate (< 26%). The mainstay of treatment for AML includes chemotherapy, but the response of… read more here.
Keywords: chromatin reader; hotspot mutations; investigating impact; mutations chromatin ... See more keywords
The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1119750
Abstract: ING5 is a component of KAT6A and KAT7 histone lysine acetylation protein complexes. ING5 contains a PHD domain that binds to histone H3 lysine 4 when it is trimethylated, and so functions as a ‘reader’… read more here.
Keywords: chromatin reader; cell; reader protein; hematopoiesis ... See more keywords