Pan‐cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4749
Abstract: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open chromatin regions is lower than that in flanking regions because of the higher accessibility of DNA repair… read more here.
Keywords: regions possible; open chromatin; mutations open; cancer ... See more keywords
SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3298
Abstract: Mouse dental papilla cells (mDPCs) derive from cranial neural crest cells and maintain mesenchymal stem cell characteristics. The differentiation of neural crest cells into odontoblasts is orchestrated by transcription factors regulating the expression of genes… read more here.
Keywords: chromatin; odontoblast lineages; chromatin regions; sall1 regulates ... See more keywords
Open Sesame: Open Chromatin Regions Shed Light onto Non-coding Risk Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.08.006
Abstract: Human genetics and stem cell biology have advanced neurobiology for neurodevelopmental psychiatric disorders. In this issue of Cell Stem Cell, Forrest et al. (2017) demonstrate that studying the landscape of open chromatin regions in stem cell-derived… read more here.
Keywords: chromatin regions; stem cell; non coding; open chromatin ... See more keywords
How noncoding open chromatin regions shape soybean domestication.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in plant science"
DOI: 10.1016/j.tplants.2021.06.008
Abstract: Open chromatin regions (OCRs), a generally conserved genomic feature amongst plant species, contain noncoding cis-regulatory elements for gene regulation. Wang et al. recently investigated how OCR structures and noncoding regions might have influenced the domestication… read more here.
Keywords: regions shape; domestication; chromatin regions; noncoding open ... See more keywords
Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.01.003
Abstract: Ascidian species of the Phallusia and Ciona genera are distantly related, their last common ancestor dating several hundred million years ago. Although their genome sequences have extensively diverged since this radiation, Phallusia and Ciona species… read more here.
Keywords: chromatin; chromatin regions; open chromatin; cis regulatory ... See more keywords
Identification of the accessible chromatin regions in six tissues in the soybean.
Sign Up to like & getrecommendations! Published in 2022 at "Genomics"
DOI: 10.1016/j.ygeno.2022.110364
Abstract: Accessible chromatin regions (ACRs) are tightly associated with gene expressions in the genome. Conserved non-coding cis-regulatory elements, such as transcription factor binding motifs, are usually found in ACRs, indicating an essential regulatory role of ACRs… read more here.
Keywords: six tissues; accessible chromatin; chromatin regions; regions six ... See more keywords
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07451-z
Abstract: During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the… read more here.
Keywords: heart; chromatin; chromatin regions; expression ... See more keywords
Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19319-2
Abstract: The chromatin landscape of human brain cells encompasses key information to understanding brain function. Here we use ATAC-seq to profile the chromatin structure in four distinct populations of cells (glutamatergic neurons, GABAergic neurons, oligodendrocytes, and… read more here.
Keywords: schizophrenia; chromatin; chromatin regions; glutamatergic neurons ... See more keywords
Selection on accessible chromatin regions in Capsella grandiflora.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msab270
Abstract: Accurate estimates of genome-wide rates and fitness effects of new mutations are essential for an improved understanding of molecular evolutionary processes. Although eukaryotic genomes generally contain a large non-coding fraction, functional non-coding regions and fitness… read more here.
Keywords: accessible chromatin; chromatin regions; selection; non coding ... See more keywords
Condensed but liquid-like domain organization of active chromatin regions in living human cells
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf1488
Abstract: In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellular functions. However, their physical nature in living cells remains unclear (e.g., condensed domains or extended fiber loops; liquid-like or solid-like). Using novel… read more here.
Keywords: liquid like; active chromatin; human cells; chromatin ... See more keywords