A framework for identifying dysregulated chromatin regulators as master regulators in human cancer
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty836
Abstract: MOTIVATION Chromatin regulators (CRs) are frequently dysregulated to reprogram the epigenetic landscape of the cancer genome. However, the underpinnings of the dysregulation of CRs and their downstream effectors remain to be elucidated. RESULTS Here, we… read more here.
Keywords: crs; chromatin regulators; cancer; framework identifying ... See more keywords
CRdb: a comprehensive resource for deciphering chromatin regulators in human
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac960
Abstract: Abstract Chromatin regulators (CRs) regulate epigenetic patterns on a partial or global scale, playing a critical role in affecting multi-target gene expression. As chromatin immunoprecipitation sequencing (ChIP-seq) data associated with CRs are rapidly accumulating, a… read more here.
Keywords: comprehensive resource; crdb; resource; chromatin regulators ... See more keywords
FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky679
Abstract: Abstract Epigenetic alterations, a well-recognized cancer hallmark, are driven by chromatin regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and less is known about their common and specialized roles… read more here.
Keywords: cancer types; across cancer; crs; chromatin regulators ... See more keywords
Construction and Validation of A Novel Predictive Model Based on Chromatin Regulators in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biomedical Nanotechnology"
DOI: 10.1166/jbn.2023.3524
Abstract: Chromatin regulators (CRs) are substantially associated with the prognosis and immunotherapy responses in multiple cancers. However, comprehensive studies related to the prognostic prediction of CRs in endometrial cancer (UCEC) still remains lacking. Therefore, first, we… read more here.
Keywords: endometrial cancer; predictive model; high risk; chromatin regulators ... See more keywords
Identification of molecular subtypes and a prognostic signature based on chromatin regulators related genes in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1110723
Abstract: The clinical and molecular phenotypes of prostate cancer (PCa) exhibit substantial heterogeneity, ranging from indolent to metastatic disease. In this study, we aimed to identify PCa subtypes and construct a gene signature that can predict… read more here.
Keywords: prostate cancer; based chromatin; signature; pca ... See more keywords
Identification and validation of differentially expressed chromatin regulators for diagnosis of aortic dissection using integrated bioinformatics analysis and machine-learning algorithms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.950613
Abstract: Background: Aortic dissection (AD) is a life-threatening disease. Chromatin regulators (CRs) are indispensable epigenetic regulators. We aimed to identify differentially expressed chromatin regulators (DECRs) for AD diagnosis. Methods: We downloaded the GSE52093 and GSE190635 datasets… read more here.
Keywords: decrs; machine; aortic dissection; machine learning ... See more keywords
A novel risk score model based on fourteen chromatin regulators-based genes for predicting overall survival of patients with lower-grade gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.957059
Abstract: Background: Low grade gliomas(LGGs) present vexatious management issues for neurosurgeons. Chromatin regulators (CRs) are emerging as a focus of tumor research due to their pivotal role in tumorigenesis and progression. Hence, the goal of the… read more here.
Keywords: risk score; grade gliomas; chromatin regulators; risk ... See more keywords
Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.961018
Abstract: Background: Hepatocellular carcinoma (HCC) is notorious for its high mortality and incidence. Accumulating evidence confirms that chromatin regulators (CRs) have a significant impact on cancer. Therefore, exploring the mode of action and prognostic value of… read more here.
Keywords: hepatocellular carcinoma; chromatin regulators; hcc patients; model ... See more keywords