FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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DOI: 10.1126/sciadv.abq4831
Abstract: Dysregulation of the Notch–RBPJ (recombination signal-binding protein of immunoglobulin kappa J region) signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its… read more here.
Keywords: notch signaling; rbpj; fbxo42; chromatin relaxation ... See more keywords