CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110626
Abstract: CTCF mediates chromatin insulation and long-distance enhancer-promoter (EP) interactions; however, little is known about how these regulatory functions are partitioned among target genes in key biological processes. Here, we show that Ctcf expression is progressively… read more here.
Keywords: ctcf; ctcf functions; pluripotency; chromatin remodeler ... See more keywords
Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-50088-1
Abstract: Medulloblastoma is a malignant pediatric tumor that arises from neural progenitors in the cerebellum. Despite a five-year survival rate of ~70%, nearly all patients incur adverse side effects from current treatment strategies that drastically impact… read more here.
Keywords: sonic hedgehog; medulloblastoma; shh; chromatin remodeler ... See more keywords
The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac827
Abstract: Abstract Centromeres of most eukaryotes consist of two distinct chromatin domains: a kinetochore domain, identified by the histone H3 variant, CENP-A, and a heterochromatic domain. How these two domains are separated is unclear. Here, we… read more here.
Keywords: heterochromatin; pericentromeric heterochromatin; chromatin; remodeler rsc ... See more keywords
The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx636
Abstract: Chd1 (Chromodomain Helicase DNA Binding Protein 1) is a conserved ATP-dependent chromatin remodeler that maintains the nucleosomal structure of chromatin, but the determinants of its specificity and its impact on gene expression are not well… read more here.
Keywords: chd1; chromatin; atp dependent; chromatin remodeler ... See more keywords
The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Science advances"
DOI: 10.1126/sciadv.abb8626
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the treatment of BRCA-deficient cancers, with treatments currently extending toward other homologous recombination defective tumors. In a genome-wide CRISPR knockout screen with olaparib, we identify ALC1 (Amplified in… read more here.
Keywords: treatment; parp inhibitor; resistance; chromatin remodeler ... See more keywords
Dual Regulatory Role of Chromatin Remodeler ISW1 in Coordinating Cellulase and Secondary Metabolite Biosynthesis in Trichoderma reesei
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03456-21
Abstract: Microorganisms, including Trichoderma reesei, constantly face the challenge to outcompete other species to ensure efficient colonization in their natural habitat. They achieve this usually by adopting two alternative strategies by either maintaining fast growth on… read more here.
Keywords: biosynthesis; trichoderma reesei; role; chromatin remodeler ... See more keywords
The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009997
Abstract: The Chd8 gene encodes a member of the chromodomain helicase DNA-binding (CHD) family of SNF2H-like adenosine triphosphate (ATP)-dependent chromatin remodeler, the mutations of which define a subtype of autism spectrum disorders. Increasing evidence from recent… read more here.
Keywords: p53 protein; stem progenitor; chd8; hematopoietic stem ... See more keywords
The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
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DOI: 10.3390/cancers15082228
Abstract: Simple Summary ATRX is one of the most frequently mutated tumor suppressor genes in human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is essential for normal development. ATRX plays a crucial… read more here.
Keywords: atrx; role; biology; chromatin remodeler ... See more keywords
Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.58130
Abstract: SWI/SNF-family chromatin remodeling complexes, such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription. Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, prompting whether and how SWI/SNF-family remodelers are specialized to remodel… read more here.
Keywords: unwrapped nucleosomes; remodel partially; partially unwrapped; specialization chromatin ... See more keywords
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.71420
Abstract: The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as… read more here.
Keywords: parylated nucleosome; structure; remodeler alc1; alc1 ... See more keywords
ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77352
Abstract: One-dimensional (1D) target search is a well characterized phenomenon for many DNA binding proteins but is poorly understood for chromatin remodelers. Herein, we characterize the 1D scanning properties of SWR1, a yeast chromatin remodeler that… read more here.
Keywords: diffusion; dna; one dimensional; chromatin remodeler ... See more keywords