Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-41283-8_5
Abstract: Base excision repair (BER) is a co-ordinated DNA repair pathway that recognises and repairs chemically modified bases and DNA single strand breaks. It is essential for the maintenance of genome integrity and thus in the… read more here.
Keywords: chromatin remodelling; base excision; chromatin; excision repair ... See more keywords
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
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DOI: 10.1038/s41388-021-01781-x
Abstract: Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequently driving oncogenic… read more here.
Keywords: chromatin remodelling; chromatin; snf chromatin; remodelling complexes ... See more keywords
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Nature biomedical engineering"
DOI: 10.1038/s41551-021-00709-w
Abstract: Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury. Using fibroblasts from porcine aortic valves cultured on hydrogels… read more here.
Keywords: nuclear mechanosensing; chromatin remodelling; activated fibroblasts; persistently activated ... See more keywords
Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population
Sign Up to like & getrecommendations! Published in 2022 at "International Review of Psychiatry"
DOI: 10.1080/09540261.2022.2072193
Abstract: Abstract Chromatin remodelling is an important process in neural development and is related to autism spectrum disorder (ASD) and schizophrenia (SCZ) aetiology. To further elucidate the involvement of chromatin remodelling genes in the genetic aetiology… read more here.
Keywords: chromatin remodelling; rare missense; missense variants; chromatin ... See more keywords
Brg1 subunit of chromatin remodelling complex is present during Chara vulgaris (Charophyceae) spermatogenesis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Phycology"
DOI: 10.1080/09670262.2018.1480803
Abstract: ABSTRACT During spermatogenesis, cells developed as a result of numerous mitotic and meiotic divisions transform into mature spermatozoids. In spermatids, remodelling of chromatin structure takes place which is connected with nuclear protein exchange, DNA double… read more here.
Keywords: brg1; chromatin remodelling; vulgaris; subunit ... See more keywords
H2A.Z and chromatin remodelling complexes: a focus on fungi
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Microbiology"
DOI: 10.1080/1040841x.2020.1781784
Abstract: Abstract Chromatin is a highly dynamic structure that closely relates with gene expression in eukaryotes. ATP-dependent chromatin remodelling, histone post-translational modification and DNA methylation are the main ways that mediate such plasticity. The histone variant… read more here.
Keywords: chromatin; chromatin remodelling; complexes focus; remodelling complexes ... See more keywords
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses
Sign Up to like & getrecommendations! Published in 2017 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0283
Abstract: Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase with a master regulatory function in the DNA damage response. In this role, ATM commands a complex biochemical network that signals the presence of oxidative DNA damage,… read more here.
Keywords: dna damage; chromatin remodelling; atm dependent; dna ... See more keywords
Chromatin-Remodelling ATPases ISWI and BRM Are Essential for Reproduction in the Destructive Pest Tuta absoluta
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063267
Abstract: The tomato leaf miner (Tuta absoluta) is one of the top 20 plant pests worldwide. We cloned and identified the chromatin-remodelling ATPase genes ISWI and BRM by RACE and bioinformatic analysis, respectively; used RT-qPCR to… read more here.
Keywords: chromatin; chromatin remodelling; iswi brm; reproduction ... See more keywords