Linker histone H1FOO regulates the chromatin structure in mouse zygotes
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13175
Abstract: The chromatin structure in one‐cell‐stage mouse embryos is extremely loose and becomes tighter at the two‐cell stage. As linker histones are involved in higher‐order chromatin structure, we examined the involvement of the linker histone variant… read more here.
Keywords: chromatin structure; h1foo; structure; cell ... See more keywords
Computational characterization of domain-segregated 3D chromatin structure and segmented DNA methylation status in carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13127
Abstract: The high-order chromatin structure, together with DNA methylation and other epigenetic marks, plays a vital role in gene regulation and displays abnormal status in cancer cells. Theoretical analyses are expected to provide a more unified… read more here.
Keywords: carcinogenesis; chromatin structure; dna methylation;
Chromatin Structure and the Pioneering Transcription Factor FOXA1 Regulate TDG-Mediated Removal of 5-Formylcytosine from DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b07576
Abstract: Although a functional relationship between active DNA demethylation and chromatin structure is often implied, direct experimental evidence is lacking. We investigated the relationship between chromatin structure and thymine DNA glycosylase (TDG) using chemically defined nucleosome… read more here.
Keywords: chromatin structure; dna; tdg; chromatin ... See more keywords
Chromatin conformation regulates the coordination between DNA replication and transcription
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03539-8
Abstract: Chromatin is the template for the basic processes of replication and transcription, making the maintenance of chromosomal integrity critical for cell viability. To elucidate how dividing cells respond to alterations in chromatin structure, here we… read more here.
Keywords: chromatin structure; chromatin; dna replication; replication transcription ... See more keywords
KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1118
Abstract: Abstract Neural differentiation of embryonic stem cells (ESCs) requires precisely orchestrated gene regulation, a process governed in part by changes in 3D chromatin structure. How these changes regulate gene expression in this context remains unclear.… read more here.
Keywords: klf4 inhibits; neural differentiation; differentiation; chromatin structure ... See more keywords
Diagnostics of DNA fragmentation in human spermatozoa: Are sperm chromatin structure analysis and sperm chromatin dispersion tests (SCD‐HaloSpermG2®) comparable?
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13316
Abstract: Men affected with idiopathic infertility often display basic spermiogramme values similar to fertile individuals, questioning the diagnostic impact of the World Health Organization (WHO) thresholds used. This study explored sperm DNA fragmentation in single ejaculates… read more here.
Keywords: chromatin; chromatin structure; sperm chromatin; dna fragmentation ... See more keywords
Resveratrol benefits on sperm DNA, chromatin structure and reproductive outcomes of varicocelized rats
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14417
Abstract: In varicocele, the main cause of sperm DNA damage is oxidative stress (OS). Resveratrol, a polyphenol with antioxidant properties, can protect cells from injuries caused by OS. We investigated the benefits of resveratrol against reproductive… read more here.
Keywords: dna; resveratrol; sperm dna; varicocele ... See more keywords
Chromatin structure related to oncogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15850
Abstract: Chromatin is the fundamental structure of genomic DNA in eukaryotic cells. The nucleosome, the primary unit of chromatin, consists of DNA and histone proteins, and is important for the maintenance of genomic DNA. Histone mutations… read more here.
Keywords: structure; histone; related oncogenesis; chromatin ... See more keywords
PO-395 Mechanistic investigation of epigenetic modifications induced by metabolic changes in AML
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.422
Abstract: Introduction Acute Myeloid Leukaemia is the most common and aggressive adult leukaemia with a high frequency of relapse and mortality. This is likely due to the failure to eliminate the malignant stem like population (LSCs)… read more here.
Keywords: chromatin structure; 395 mechanistic; metabolic changes; bcat1 ... See more keywords
Abstract A25: Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.aacrahns19-a25
Abstract: Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) represents a unique disease entity within head and neck cancer with rising incidence. Previous work has shown that alternative splicing events (ASEs) are prevalent in HPV+ OPSCC,… read more here.
Keywords: chromatin structure; cancer specific; hpv; cancer ... See more keywords
Exploring the relationship between intron retention and chromatin accessibility in plants
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-4393-z
Abstract: BackgroundIntron retention (IR) is the most prevalent form of alternative splicing in plants. IR, like other forms of alternative splicing, has an important role in increasing gene product diversity and regulating transcript functionality. Splicing is… read more here.
Keywords: chromatin structure; chromatin; chromatin accessibility; retention ... See more keywords