RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells
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DOI: 10.1038/s41588-018-0060-9
Abstract: Ten-eleven translocation (TET) proteins play key roles in the regulation of DNA-methylation status by oxidizing 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), which can both serve as a stable epigenetic mark and participate in active demethylation.… read more here.
Keywords: gene regulation; chromatin targeting; rna dependent; chromatin ... See more keywords
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
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DOI: 10.26508/lsa.202302282
Abstract: The E3 ubiquitin ligase RNF12/RLIM is mutated in intellectual disability and controls developmental gene expression. We show that chromatin targeting of RNF12 is required for substrate ubiquitylation and transcriptional responses, providing insight into mechanisms by… read more here.
Keywords: transcriptional responses; chromatin targeting; rnf12 rlim; ubiquitin ligase ... See more keywords