Synthesis, determination of analytical characteristics and differentiation of positional isomers in the series of N-(2-methoxybenzyl)-2-(dimethoxyphenyl)ethanamine by means of chromatography-mass spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2859
Abstract: N-(2-Methoxybenzyl)-2,5-dimethoxyphenethylamines (NBOMes) are synthetic phenethylamine derivatives emerging on the drugs of abuse market and reported to be associated with untoward effects in people using drugs. The mechanism of action involves agonism at serotonin 5-HT2A receptors… read more here.
Keywords: mass spectrometry; 25h nbome; differentiation positional; mass ... See more keywords
Potential of chromatography and mass spectrometry for the differentiation of three series of positional isomers of 2-(dimethoxyphenyl)-N-(2-halogenobenzyl)ethanamines.
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DOI: 10.1002/dta.3232
Abstract: N-(2-Substituted benzyl)-2,5-dimethoxyphenethylamines often cause severe poisonings which has led to their legal prohibition in many countries. At the same time, their positional isomers can be studied as potential therapeutic drugs. In this regard, the search… read more here.
Keywords: differentiation; chromatography mass; mass spectrometry; chromatography ... See more keywords
A simple and easy non-derivatization gas chromatography-mass spectrometry method for simultaneous quantification of valproic acid, gabapentin, pregabalin, and vigabatrin in human plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200622
Abstract: Immunoassays are currently not available in commercial kits for the quantification of valproic acid, vigabatrin, pregabalin, and gabapentin, which also cannot suffer the limitations of interferences of substances with similar structures. Chromatography is a good… read more here.
Keywords: gas chromatography; chromatography mass; mass spectrometry; plasma ... See more keywords
Impact of sample containers on gas chromatography mass spectrometry based plasma untargeted and targeted metabolomics
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DOI: 10.1002/pmic.202000196
Abstract: Plasticware and glassware used in the sample processing stage could result in different analysis performance for macromolecules, which led to the speculation that a similar effect could happen to small molecules. To confirm the speculation,… read more here.
Keywords: gas chromatography; mass spectrometry; targeted metabolomics; chromatography mass ... See more keywords
Measuring Activity of Cholesterol Synthesis Enzymes Using Gas Chromatography/Mass Spectrometry.
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DOI: 10.1007/978-1-4939-6875-6_16
Abstract: The development of gas chromatography/mass spectrometry (GC/MS) technology has improved the ease and efficiency with which sterols in biological samples can be analyzed. Its advantages include that it needs only a small amount of sample,… read more here.
Keywords: gas chromatography; mass spectrometry; cholesterol synthesis; chromatography mass ... See more keywords
Untargeted Soil Metabolomics Using Liquid Chromatography-Mass Spectrometry and Gas Chromatography-Mass Spectrometry.
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DOI: 10.1007/978-1-4939-8757-3_4
Abstract: The molecular composition of soil organic matter (SOM) sets the foundation for terrestrial microbial community structures and carbon cycling dynamics. However, the specific chemical constituents of SOM are underexplored. In this chapter we present a… read more here.
Keywords: chromatography mass; using liquid; mass spectrometry;
Comprehensive Two-Dimensional Gas Chromatography Mass Spectrometry-Based Metabolomics.
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DOI: 10.1007/978-3-030-51652-9_4
Abstract: Compared to one-dimensional gas chromatography with mass spectrometry (GC-MS), GC × GC-MS provides significantly increased peak capacity, resolution, and sensitivity for analysis of complex biological samples. In the last decade, GC × GC-MS has been increasingly applied to the… read more here.
Keywords: gas chromatography; mass spectrometry; mass; chromatography mass ... See more keywords
A direct comparison of liquid chromatography-mass spectrometry with clinical routine testing immunoassay methods for the detection and quantification of thyroid hormones in blood serum
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01724-2
Abstract: AbstractA new and improved method was developed for the determination and quantification of four “free” thyroid hormones (i.e. 3,5-diiodothyronine (T2), 3,3′,5-triiodothyronine (T3), 3,3′,5′-triiodothyrone (rT3) and 3,5,3′,5′-tetraiodothyronine (T4)) in human serum by low- and high-resolution liquid… read more here.
Keywords: phase; chromatography mass; liquid chromatography; thyroid hormones ... See more keywords
Identification and characterisation of odorants in a squishy toy using gas chromatography-mass spectrometry/olfactometry after thermal extraction
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DOI: 10.1007/s00216-019-01860-9
Abstract: Soft, squashable toys known as squishies have become increasingly popular amongst children. In this study, one such toy was evaluated sensorially by a trained panel and analytically using gas chromatography-mass spectrometry/olfactometry (GC-MS/O) after thermal extraction… read more here.
Keywords: gas chromatography; mass spectrometry; olfactometry thermal; spectrometry olfactometry ... See more keywords
Countercurrent chromatographic fractionation followed by gas chromatography/mass spectrometry identification of alkylresorcinols in rye
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DOI: 10.1007/s00216-020-02980-3
Abstract: Alkylresorcinols (5-alkyl-1,3-dihydroxybenzenes, ARs) are bioactive phenolic lipid compounds which are particularly abundant in rye and partly other cereals. In this study on ARs, whole rye grain extracts were gained with cyclohexane/ethyl acetate (46/54, w/w). Silylated… read more here.
Keywords: gas chromatography; chromatography mass; countercurrent chromatographic; mass spectrometry ... See more keywords
Profiling the Photochemical-Induced Degradation of Rat Growth Hormone with Extreme Ultra-pressure Chromatography–Mass Spectrometry Utilizing Meter-Long Microcapillary Columns Packed with Sub-2-µm Particles
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DOI: 10.1007/s10337-017-3344-9
Abstract: In recent years, protein therapeutics have seen increasing use in the therapeutic arena. As with traditional small molecule drug substances, one is obligated to ensure purity and stability of the various dosage forms. With these… read more here.
Keywords: chromatography; degradation; system; chromatography mass ... See more keywords