New method for the synthesis of chromeno[4,3-b]chromene derivatives via multicomponent reaction promoted by niobium pentachloride
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.01.062
Abstract: Abstract Chromeno[4,3-b]chromene derivatives were synthesized from multicomponent reaction between 4-hydroxycoumarin, aryl aldehyde derivatives and 1,3-cyclohexanedione promoted by niobium pentachloride. This new method is simple, cost-effective, provides good yields with good substrate generality and can be… read more here.
Keywords: multicomponent reaction; promoted niobium; chromene derivatives; reaction ... See more keywords
Rapid and catalyst free synthesis of new bis(benzo[g]chromene) and bis(pyrano[3,2-c]chromene) derivatives and optimization of reaction conditions using response surface methodology
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07809f
Abstract: One-pot synthesis of C2-symmetric chromene derivatives, which serve as building blocks to prepare liquid crystals with potential electrical or optical properties. read more here.
Keywords: methodology; rapid catalyst; chromene; chromene derivatives ... See more keywords
Anticancer SAR Establishment and α/β-Tubulin Isoforms Specific Targeting: A Detailed Insight of Anticancer potential of 4H-Chromene derivatives
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d2nj04822a
Abstract: 4H-Chromene derivatives are promising anticancer compounds known to bind within the colchicine binding site of tubulin protein. Among these 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile based 4H-Chromenes scaffold is known to produce a significant impact... read more here.
Keywords: chromene derivatives; establishment tubulin; chromene; anticancer sar ... See more keywords
Synthesis and In Vitro Cytotoxicity of Novel Halogenated Dihydropyrano[3,2-b]Chromene Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2022.7754
Abstract: Lung and breast cancers are among the most common cancers. In the present work, initially, 6-bromo-; and 6-chloro-3-hydroxychromone compounds were prepared. In the next step, a series of 8-bromo-; and 8-chloro-dihyropyrano[3,2-b]chromene derivatives were synthesized by… read more here.
Keywords: chromene derivatives; vitro cytotoxicity; chromene; synthesis vitro ... See more keywords
Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15050548
Abstract: In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to… read more here.
Keywords: chromene derivatives; selective terra; derivatives selective; rna ... See more keywords
Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights
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DOI: 10.3390/ph16030333
Abstract: Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent reaction using N-alkyl-1H-indole-3-carbaldehydes, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile, catalysed by DBU at 60–65 °C in a short reaction time. The benefits of the methodology include non-toxicity, an uncomplicated… read more here.
Keywords: chromene derivatives; novel indole; derivatives synthesis; cytotoxic ... See more keywords
Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14122656
Abstract: Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to… read more here.
Keywords: dengue fever; dengue virus; chromene; chromene derivatives ... See more keywords