New method for the synthesis of chromeno[4,3-b]chromene derivatives via multicomponent reaction promoted by niobium pentachloride
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.01.062
Abstract: Abstract Chromeno[4,3-b]chromene derivatives were synthesized from multicomponent reaction between 4-hydroxycoumarin, aryl aldehyde derivatives and 1,3-cyclohexanedione promoted by niobium pentachloride. This new method is simple, cost-effective, provides good yields with good substrate generality and can be… read more here.
Keywords: multicomponent reaction; promoted niobium; chromene derivatives; reaction ... See more keywords
Rapid and catalyst free synthesis of new bis(benzo[g]chromene) and bis(pyrano[3,2-c]chromene) derivatives and optimization of reaction conditions using response surface methodology
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07809f
Abstract: One-pot synthesis of C2-symmetric chromene derivatives, which serve as building blocks to prepare liquid crystals with potential electrical or optical properties. read more here.
Keywords: methodology; rapid catalyst; chromene; chromene derivatives ... See more keywords
Anticancer SAR Establishment and α/β-Tubulin Isoforms Specific Targeting: A Detailed Insight of Anticancer potential of 4H-Chromene derivatives
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d2nj04822a
Abstract: 4H-Chromene derivatives are promising anticancer compounds known to bind within the colchicine binding site of tubulin protein. Among these 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile based 4H-Chromenes scaffold is known to produce a significant impact... read more here.
Keywords: chromene derivatives; establishment tubulin; chromene; anticancer sar ... See more keywords
Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra02143f
Abstract: A new series of 2-imino or 2-oxo-2H-chromene-6-sulfonamide derivatives 2–9 with potential anti-diabetic activity were designed and synthesized. The new 6-sulfonamide chromenes were synthesized by reacting 3-formyl-4-hydroxybenzenesulfonyl chloride with activated methylene derivatives in the presence of… read more here.
Keywords: ppar; sulfonamide chromene; ic50 values; innovation sulfonamide ... See more keywords
pTSA-catalyzed synthesis of functionalized chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra06198a
Abstract: In this study, an efficient and convenient three-component cyclization protocol is presented for the development of synthetically important chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via pTSA-catalyzed reaction of substituted salicylaldehyde, 1,3-dimethylbarbituric acid/4-hydroxycoumarin, and electron-rich arenes at 80 °C in… read more here.
Keywords: pyrimidine chromeno; chromeno pyrimidine; chromeno chromene; chromene derivatives ... See more keywords
Synthesis and In Vitro Cytotoxicity of Novel Halogenated Dihydropyrano[3,2-b]Chromene Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2022.7754
Abstract: Lung and breast cancers are among the most common cancers. In the present work, initially, 6-bromo-; and 6-chloro-3-hydroxychromone compounds were prepared. In the next step, a series of 8-bromo-; and 8-chloro-dihyropyrano[3,2-b]chromene derivatives were synthesized by… read more here.
Keywords: chromene derivatives; vitro cytotoxicity; chromene; synthesis vitro ... See more keywords
Evaluating the cytotoxic effects of some chlorinated substituted 2-amino-3-carbonitrile chromene derivatives on 3T3 and MCF-7 cell lines.
Sign Up to like & getrecommendations! Published in 2025 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2025.9331
Abstract: Cancer remains a leading cause of death worldwide, necessitating novel therapeutic approaches. In this study we synthesized and characterized 2-amino-3-carbonitrile chromene derivatives and evaluated their cytotoxic effects on 3T3 and MCF-7 cell lines. Characterization included… read more here.
Keywords: chromene derivatives; cell; cytotoxic effects; carbonitrile chromene ... See more keywords
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies.
Sign Up to like & getrecommendations! Published in 2024 at "Current topics in medicinal chemistry"
DOI: 10.2174/0115680266305231240712104736
Abstract: Synthetic routes of chromene are an area of thrust research due to its wide application as pigments, agrochemicals, cosmetics, and an important nucleus scaffold for various pharmaco-logically active drugs. The chromene nucleus is an important… read more here.
Keywords: review; chromene derivatives; eco friendly; friendly approaches ... See more keywords
Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15050548
Abstract: In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to… read more here.
Keywords: chromene derivatives; selective terra; derivatives selective; rna ... See more keywords
Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030333
Abstract: Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent reaction using N-alkyl-1H-indole-3-carbaldehydes, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile, catalysed by DBU at 60–65 °C in a short reaction time. The benefits of the methodology include non-toxicity, an uncomplicated… read more here.
Keywords: chromene derivatives; novel indole; derivatives synthesis; cytotoxic ... See more keywords
Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14122656
Abstract: Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to… read more here.
Keywords: dengue fever; dengue virus; chromene; chromene derivatives ... See more keywords