1H‐1,2,3‐Triazole−4H‐chromene−D‐glucose hybrid compounds: Synthesis and inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200459
Abstract: A series of 1H‐1,2,3‐triazole−4H‐chromene−D‐glucose hybrid compounds 7a–w were synthesized using click chemistry of 2‐amino‐7‐propargyloxy‐4H‐chromene‐3‐carbonitriles 5a–w. CuNPs@montmorillonite was used as a catalyst in the presence of DIPEA as an additive for this chemistry. All synthesized 1H‐1,2,3‐triazoles… read more here.
Keywords: chemistry; chromene; glucose hybrid; protein ... See more keywords
Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.060
Abstract: The series of 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles 5a-t were synthesized from corresponding 2-amino-7-phydroxy-4H-chromene-3-carbonitriles 4a-t and propargyl bromide. Two procedures were used in these syntheses: K2CO3/acetone and NaH/DMF procedures with yields of 65-89% and 80-96%, respectively. 1H-1,2,3-Triazole-tethered 4H-chromene-d-glucose conjugates… read more here.
Keywords: chromene; chromene glucose; chemistry; tethered chromene ... See more keywords