Articles with "chromeno pyridine" as a keyword



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Pot, atom and step economic (PASE) assembly of salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones into medicinally relevant 5H-chromeno[2,3-b]pyridine scaffold

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Published in 2019 at "Molecular Diversity"

DOI: 10.1007/s11030-019-09968-x

Abstract: The new multicomponent reaction (MCR) has been found: one-pot selective and efficient formation of the new 5-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-substituted 5H-chromeno[2,3-b]pyridines in 61–97% yields directly from simple and easily available salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones in small amount… read more here.

Keywords: hydroxypyridine ones; pyridine; dimer hydroxypyridine; chromeno pyridine ... See more keywords
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Multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and pyrazolin-5-ones into substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles

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Published in 2018 at "Russian Chemical Bulletin"

DOI: 10.1007/s11172-018-2278-1

Abstract: A new multicomponent reaction, namely, a one-pot transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 2-pyrazolin-5-ones in the presence of triethylamine as the catalyst in a minimum amount of propanol leads to the previously unknown substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno [2,3-b]-… read more here.

Keywords: chromeno pyridine; substituted diamino; transformation salicylaldehydes;
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Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

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Published in 2018 at "Synlett"

DOI: 10.1055/s-0036-1591535

Abstract: This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows… read more here.

Keywords: reaction intermediates; blaise reaction; functionalized chromeno; chromeno pyridine ... See more keywords

Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity

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Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24097724

Abstract: About twenty molecules sharing 1H-chromeno[3,2-c]pyridine as the scaffold and differing in the degree of saturation of the pyridine ring, oxidation at C10, 1-phenylethynyl at C1 and 1H-indol-3-yl fragments at C10, as well as a few… read more here.

Keywords: chromeno pyridine; pyridine; activity; chemical biological ... See more keywords