Chromium-Catalyzed Defluorinative Reductive Coupling of Aldehydes with gem-Difluoroalkenes.
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DOI: 10.1021/acs.orglett.3c00016
Abstract: Herein, a mild and convenient defluorinative reductive cross coupling of gem-difluoroalkenes with aliphatic aldehydes has been developed to afford diverse silyl-protected β-fluorinated allylic alcohols. The reaction is operationally simple and shows good functional group tolerance… read more here.
Keywords: catalyzed defluorinative; defluorinative reductive; gem difluoroalkenes; reductive coupling ... See more keywords
Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
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DOI: 10.1038/s41467-018-07069-1
Abstract: Selective creation of quaternary carbon centers has been a long-standing challenge in synthetic chemistry. We report here the chromium-catalyzed, para-selective formation of arylated quaternary carbon centers by alkylative reactions of benzamide derivatives with tertiary alkylmagnesium… read more here.
Keywords: chromium catalyzed; carbon; carbon centers; para selective ... See more keywords
N-Heterocyclic carbene-chromium-catalyzed alkylative cross-coupling of benzamide derivatives with aliphatic bromides.
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DOI: 10.1039/c8cc05026k
Abstract: Described here is a chromium-catalyzed alkylative cross-coupling of benzamide derivatives with aliphatic electrophiles under mild conditions. This reaction was promoted by a low-cost and air-stable chromium(iii) chloride salt combined with an N-heterocyclic carbene ligand and… read more here.
Keywords: chromium catalyzed; coupling benzamide; catalyzed alkylative; chromium ... See more keywords
Chromium-catalyzed cyclopropanation of alkenes with bromoform in the presence of 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-dihydropyrazine†
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DOI: 10.1039/d0sc00964d
Abstract: Chromium-catalyzed cyclopropanation of alkenes with bromoform was achieved to produce the corresponding bromocyclopropanes. In this catalytic cyclopropanation, an organosilicon reductant, 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-dihydropyrazine (1a), was indispensable for reducing CrCl3(thf)3 to CrCl2(thf)3, as well as for in situ… read more here.
Keywords: cyclopropanation; chromium catalyzed; cyclopropanation alkenes; alkenes bromoform ... See more keywords
Chromium-catalyzed olefination of arylaldehydes with haloforms assisted by 2,3,5,6-tetramethyl-N,N'-bis(trimethylsilyl)-1,4-dihydropyrazine.
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DOI: 10.1039/d2cc06104j
Abstract: Chromium-catalyzed olefination of arylaldehydes with haloforms was achieved using 2,3,5,6-tetramethyl-N,N'-bis(trimethylsilyl)-1,4-dihydropyrazine (1a) as an organic reducing agent, giving β-halostyrene derivatives in a trans-selective manner. The reaction required no metal powders, such as zinc and manganese, as… read more here.
Keywords: arylaldehydes haloforms; olefination arylaldehydes; chromium catalyzed; bis trimethylsilyl ... See more keywords
Chromium-Catalyzed Asymmetric Dearomatization–Addition Reactions of Halomethyloxazoles and Indoles
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DOI: 10.1055/s-0037-1609753
Abstract: The asymmetric dearomatization–addition reaction of halomethyloxazoles and halomethylindoles with aldehydes is realized in the presence of a carbazole-based bisoxazoline CrCl2 complex to afford the corresponding enantioenriched, hydroxylated oxazoline and indoline products. The observed excellent chemo-,… read more here.
Keywords: asymmetric dearomatization; chromium catalyzed; dearomatization addition; catalyzed asymmetric ... See more keywords