KSCN‐mediated one‐pot thiocyanation tandem cyclization of enaminones: a facile access to 2‐amino/imino thiazolo fused chromone and coumarin frameworks
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400690
Abstract: A rapid metal‐free approach describing one‐pot thiocyanation of chromone and coumarin enabling tandem cyclization via potassium thiocyanate as a sulfur surrogate was unveiled. Interestingly, this enaminone‐mediated protocol facilitated straightforward access to medicinally significant 2‐amino/imino thiazolo… read more here.
Keywords: one pot; tandem cyclization; pot thiocyanation; chromone ... See more keywords
Design and synthesis of novel benzyloxy-tethered-chromone-carboxamide derivatives as potent and selective human monoamine oxidase-b inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01332-w
Abstract: A series of new bifunctional 7-benzyloxy-2, 3-dimethyl-4-oxo-4H-chromene-8-carboxamides 5a - 5 l were synthesized from 7-hydroxy 2,3 dimethyl chromone via key intermediate 7-benzyloxy 2,3 dimethyl-8-carboxylic acid using Jones oxidation and HBTU/HOBt (Hexafluorophosphate Benzotriazole Tetramethyl Uronium/Hydroxybenzotriazole) as selective… read more here.
Keywords: benzyloxy; human monoamine; chromone; monoamine oxidase ... See more keywords
Electronic [UV–Visible] and vibrational [FT-IR] investigation and NMR spectroscopic analysis of some halogen substituted chromone (6-Fluorochromone, 6-Chlorochromone, 6-Bromochromone)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.02.016
Abstract: Abstract This work deals with the successful spectroscopic properties (infrared, Nuclear magnetic resonance and UV–Vis) and theoretical calculations of chromone and some 6-halogen substituted chromone [C9O2H5X (X: F, Cl and Br)] molecules, namely Chromone (Chr),… read more here.
Keywords: substituted chromone; fluorochromone; chromone; halogen substituted ... See more keywords
Chromone-Based Antioxidant Copper(II) Complex with High Superoxide Dismutase Activity.
Sign Up to like & getrecommendations! Published in 2025 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.5c04045
Abstract: Various low-molecular weight transition metal complexes mimic the function of superoxide dismutase enzymes (SODs) and can be applied as antioxidants in the medical treatment of diseases associated with elevated superoxide levels. In this aspect, chromone… read more here.
Keywords: chromone based; copper complex; copper; superoxide dismutase ... See more keywords
Effect of the Chromone Core Substitution of Dirchromone on the Resultant Biological Activities.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00385
Abstract: Dirchromone is a bioactive vinyl sulfoxide-bearing chromone first isolated from the shrub Dirca palustris. Altogether, 32 of its derivatives were prepared to assess the effect of substitution of its chromone core upon activities against cancer… read more here.
Keywords: dirchromone; effect; substitution; chromone ... See more keywords
[1,3]-Carboxylic Ester Transfer Reactions: Synthesis of Structurally Challenging Bisindolylmethyl Chromone Hybrids.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c04120
Abstract: Herein, we report the first example of a [1,3]-carboxylic ester transfer reaction of chromone-based α-keto esters with indoles for the efficient synthesis of densely functionalized bisindolylmethyl chromone hybrids. These structurally challenging products, including two bisindolylmethane… read more here.
Keywords: structurally challenging; carboxylic ester; chromone hybrids; ester transfer ... See more keywords
Diversity-oriented synthesis of chromone inden-1-one-fused cyclopentadienylides and C-acylated chromone adducts via allylic phosphorus ylides.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc03210a
Abstract: An organophosphine-controlled diversity-oriented synthesis of chromone inden-1-one-fused cyclopentadienylides and C-acylated 2-((chromone-3-yl)methylene)-indandiones is reported. Key attributes of the methodology are the in situ generation of an allylic P-ylide and subsequent regio- and chemoselective intramolecular cyclization reactions… read more here.
Keywords: diversity oriented; synthesis chromone; chromone inden; inden one ... See more keywords
Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2134358
Abstract: Abstract Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were… read more here.
Keywords: chromone; iron; iron chelating; activity ... See more keywords
The Monitoring and Cell Imaging of Fe3+ Using a Chromone-Based Fluorescence Probe
Sign Up to like & getrecommendations! Published in 2024 at "Molecules"
DOI: 10.3390/molecules29071504
Abstract: A new structurally simple fluorescent CP probe based on chromone was designed and synthesized, and its structure was fully characterized using various analytical techniques. The CP probe displays a high selectivity and sensitivity for sensing… read more here.
Keywords: fluorescence; cell imaging; monitoring cell; imaging fe3 ... See more keywords