Analysis of Chromosomal Alterations in Urothelial Carcinoma.
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DOI: 10.1007/978-1-4939-7234-0_1
Abstract: Here, we describe the use of complementary techniques applicable to different types of samples to analyze chromosomal alterations in urothelial carcinoma. By a conventional chromosome analysis on fresh biopsies, it is possible to delineate the… read more here.
Keywords: alterations urothelial; biology; urothelial carcinoma; analysis chromosomal ... See more keywords
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
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DOI: 10.1038/s41467-020-20565-7
Abstract: Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with a heightened risk of leukemia development. Owing to… read more here.
Keywords: risk; gene mutations; clonal hematopoiesis; gene ... See more keywords
Chromosomal alterations among age-related haematopoietic clones in Japan
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DOI: 10.1038/s41586-020-2426-2
Abstract: The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood… read more here.
Keywords: haematopoietic clones; age; lymphocytic leukaemia; chronic lymphocytic ... See more keywords
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.
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DOI: 10.1038/s41591-021-01371-0
Abstract: Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic… read more here.
Keywords: risk; diverse types; hematopoietic mosaic; mosaic chromosomal ... See more keywords
Abstract 3507: Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing
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DOI: 10.1158/1538-7445.am2023-3507
Abstract: Mosaic mutations in blood are common with increasing age and are prognostic markers for cancer, cardiovascular dysfunction and other diseases. This group of acquired mutations include megabase-scale mosaic chromosomal alterations (mCAs). These large mutations have… read more here.
Keywords: mosaic chromosomal; genome sequencing; mcas; chromosomal alterations ... See more keywords
Profile of Chromosomal Alterations, Chromosomal Instability and Clonal Heterogeneity in Colombian Farmers Exposed to Pesticides
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.820209
Abstract: Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances.… read more here.
Keywords: clonal heterogeneity; instability; chromosomal alterations; exposed pesticides ... See more keywords