Stability and low induction propensity of cefiderocol against chromosomal AmpC β-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae
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DOI: 10.1093/jac/dky482
Abstract: Objectives: The siderophore cephalosporin cefiderocol possesses in vitro activity against MDR Gram-negative bacteria. The stability of cefiderocol against serine- and metallo-type carbapenemases has been reported previously, but little is known about how cefiderocol interacts with… read more here.
Keywords: chromosomal ampc; induction; ampc lactamases; cefiderocol ... See more keywords
Overproduction of Chromosomal ampC β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates
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DOI: 10.1128/spectrum.00058-22
Abstract: This study is the first to demonstrate that mutations in the chromosomal-ampC attenuator region are responsible for the emergence of cefazolin resistance in Escherichia coli strains. The resistance was maintained even after culturing E. coli… read more here.
Keywords: chromosomal ampc; escherichia coli; resistance; coli strains ... See more keywords