cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.009
Abstract: Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in the human genome. Although many have recently been linked to complex human traits, the underlying mechanisms for most of these transcripts remain undetermined. We… read more here.
Keywords: trait; trait associated; trait relevant; chromosomal architecture ... See more keywords
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2104070
Abstract: ABSTRACT Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent on expression of RANKL by MM cells. Notably, costimulation by ITAM containing… read more here.
Keywords: architecture rank; pathology; myeloma; chromosomal architecture ... See more keywords
Role of chromosomal architecture in germinal center B cells and lymphomagenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000505
Abstract: PURPOSE OF REVIEW Chromatin organization during interphase is nonrandom, and dictated by a delicate equilibrium between biophysics, transcription factor expression, and topological regulators of the chromatin. Emerging evidence demonstrate a role for chromosomal conformation at… read more here.
Keywords: role; development; role chromosomal; chromosomal conformation ... See more keywords