Engineering large-scale chromosomal deletions by CRISPR-Cas9.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab557
Abstract: Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic advantage. However, due to their large size it has been difficult… read more here.
Keywords: large scale; scale chromosomal; deletions crispr; chromosomal deletions ... See more keywords
Chromosomal deletions mediated by CRISPR/Cas9 in Helicoverpa armigera
Sign Up to like & getrecommendations! Published in 2019 at "Insect Science"
DOI: 10.1111/1744-7917.12570
Abstract: Helicoverpa armigera, cotton bollworm, is one of the most disastrous pests worldwide, threatening various food and economic crops. Functional genomic tools may provide efficient approaches for its management. The clustered regularly interspaced short palindromic repeats… read more here.
Keywords: chromosomal deletions; helicoverpa armigera; cas9; crispr cas9 ... See more keywords
Targeted capture enrichment assay for non-invasive prenatal testing of large and small size sub-chromosomal deletions and duplications
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0171319
Abstract: Noninvasive prenatal testing (NIPT) using whole genome and targeted sequencing has become increasingly accepted for clinical detection of Trisomy 21 and sex chromosome aneuploidies. Few studies have shown that sub-chromosomal deletions or duplications associated with… read more here.
Keywords: targeted capture; chromosomal deletions; deletions duplications; sub chromosomal ... See more keywords
Large chromosomal deletions and impaired homologous recombination repairing in HEK293T cells exposed to polychlorinated biphenyl 153
Sign Up to like & getrecommendations! Published in 2021 at "PeerJ"
DOI: 10.7717/peerj.11816
Abstract: Background Polychlorinated biphenyls (PCBs) are persistent pollutants with carcinogenesis and mutagenesis effects which have been closely associated with PCBs-induced DNA damage. However, the detailed DNA damage events and corresponding pathway alterations under PCBs poisoning is… read more here.
Keywords: hek293t cells; large chromosomal; homologous recombination; chromosomal deletions ... See more keywords