YY2/BUB3 Axis promotes SAC Hyperactivation and Inhibits Colorectal Cancer Progression via Regulating Chromosomal Instability
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308690
Abstract: Spindle assembly checkpoint (SAC) is a crucial safeguard mechanism of mitosis fidelity that ensures equal division of duplicated chromosomes to the two progeny cells. Impaired SAC can lead to chromosomal instability (CIN), a well‐recognized hallmark… read more here.
Keywords: sac; chromosomal instability; bub3; tumor ... See more keywords
Morphological markers of chromosomal instability in bone marrow aspiration and trephine biopsy of acute leukemia and myelodysplastic syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22513
Abstract: The role of chromosomal instability (CI) in oncogenesis is very well described in solid tumours, but there are a lack of studies on haematology malignancy, especially with multiple morphological markers. The study aims to analyze… read more here.
Keywords: morphological markers; bone marrow; biopsy acute; chromosomal instability ... See more keywords
Sites of chromosomal instability in the context of nuclear architecture and function
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03698-2
Abstract: Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin that appear as breaks or gaps mostly tracing back to a loosened structure and not a real nicked break within the DNA… read more here.
Keywords: fragile sites; nuclear architecture; chromosomal instability; instability context ... See more keywords
Chromosomal instability analysis and regional tumor heterogeneity in colon cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2016.11.001
Abstract: Chromosomal instability (CIN) is classically defined as an increase in the rate at which numerical or structural chromosomal aberrations are acquired in a cancer cell. The number of somatic copy number abnormalities (CNAs) revealed by… read more here.
Keywords: analysis; number; chromosomal instability; cancer ... See more keywords
Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.08.021
Abstract: Most sporadic carcinomas with high metastatic activity show an increased rate of changes in chromosome structure and number, known as chromosomal instability (CIN). However, the role of CIN in driving invasiveness remains unclear. Using an… read more here.
Keywords: cin; induces cellular; instability induces; chromosomal instability ... See more keywords
Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104074
Abstract: Summary Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify… read more here.
Keywords: instability drives; drives convergent; convergent divergent; chromosomal instability ... See more keywords
Studying the role of chromosomal instability (CIN) in GI cancers using patient-derived organoids.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167256
Abstract: Chromosomal instability (CIN) is associated with the initiation and progression of gastrointestinal (GI) tract cancers. Cancers of the GI tract are typically characterized by altered chromosome numbers. While the dynamics of CIN have been extensively… read more here.
Keywords: cin; instability cin; cin cancers; chromosomal instability ... See more keywords
Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
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DOI: 10.1038/ncomms14257
Abstract: Infections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection… read more here.
Keywords: epstein barr; chromosomal instability; centrosome amplification; virus ... See more keywords
The two sides of chromosomal instability: drivers and brakes in cancer
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DOI: 10.1038/s41392-024-01767-7
Abstract: Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural… read more here.
Keywords: replication; cancer; chromosomal instability; tumor ... See more keywords
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03828-2
Abstract: Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches… read more here.
Keywords: ctcf binding; chromosomal instability; binding sites; non coding ... See more keywords
Chromosomal instability in human trophoblast stem cells and placentas
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DOI: 10.1038/s41467-025-59245-9
Abstract: The human placenta, a unique tumor-like organ, is thought to exhibit rare aneuploidy associated with adverse pregnancy outcomes. Discrepancies in reported aneuploidy prevalence in placentas stem from limitations in modeling and detection methods. Here, we… read more here.
Keywords: stem cells; aneuploidy; trophoblast; chromosomal instability ... See more keywords