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   Articles with "chromosomal instability" as a keyword



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Morphological markers of chromosomal instability in bone marrow aspiration and trephine biopsy of acute leukemia and myelodysplastic syndrome

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recommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22513

Abstract: The role of chromosomal instability (CI) in oncogenesis is very well described in solid tumours, but there are a lack of studies on haematology malignancy, especially with multiple morphological markers. The study aims to analyze… read more here.

Keywords: morphological markers; bone marrow; biopsy acute; chromosomal instability ... See more keywords
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Sites of chromosomal instability in the context of nuclear architecture and function

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recommendations! Published in 2020 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-020-03698-2

Abstract: Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin that appear as breaks or gaps mostly tracing back to a loosened structure and not a real nicked break within the DNA… read more here.

Keywords: fragile sites; nuclear architecture; chromosomal instability; instability context ... See more keywords
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Chromosomal instability analysis and regional tumor heterogeneity in colon cancer.

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recommendations! Published in 2017 at "Cancer genetics"

DOI: 10.1016/j.cancergen.2016.11.001

Abstract: Chromosomal instability (CIN) is classically defined as an increase in the rate at which numerical or structural chromosomal aberrations are acquired in a cancer cell. The number of somatic copy number abnormalities (CNAs) revealed by… read more here.

Keywords: analysis; number; chromosomal instability; cancer ... See more keywords
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Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues.

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recommendations! Published in 2018 at "Developmental cell"

DOI: 10.1016/j.devcel.2018.08.021

Abstract: Most sporadic carcinomas with high metastatic activity show an increased rate of changes in chromosome structure and number, known as chromosomal instability (CIN). However, the role of CIN in driving invasiveness remains unclear. Using an… read more here.

Keywords: cin; induces cellular; instability induces; chromosomal instability ... See more keywords
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Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages

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recommendations! Published in 2022 at "iScience"

DOI: 10.1016/j.isci.2022.104074

Abstract: Summary Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify… read more here.

Keywords: instability drives; drives convergent; convergent divergent; chromosomal instability ... See more keywords
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Studying the role of chromosomal instability (CIN) in GI cancers using patient-derived organoids.

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recommendations! Published in 2021 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2021.167256

Abstract: Chromosomal instability (CIN) is associated with the initiation and progression of gastrointestinal (GI) tract cancers. Cancers of the GI tract are typically characterized by altered chromosome numbers. While the dynamics of CIN have been extensively… read more here.

Keywords: cin; instability cin; cin cancers; chromosomal instability ... See more keywords
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Epstein–Barr virus particles induce centrosome amplification and chromosomal instability

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14257

Abstract: Infections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection… read more here.

Keywords: epstein barr; chromosomal instability; centrosome amplification; virus ... See more keywords
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Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-03828-2

Abstract: Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches… read more here.

Keywords: ctcf binding; chromosomal instability; binding sites; non coding ... See more keywords
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cGAS–STING signalling in cancer: striking a balance with chromosomal instability

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recommendations! Published in 2023 at "Biochemical Society Transactions"

DOI: 10.1042/bst20220838

Abstract: Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the form of micronuclei and chromatin… read more here.

Keywords: cgas sting; signalling cancer; chromosomal instability; sting signalling ... See more keywords
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Study of the Chromosomal Abnormalities and Associated Complex Karyotypes in Hematological Cancer in the Population of West Bengal: A Prospective Observational Study

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recommendations! Published in 2021 at "Indian Journal of Medical and Paediatric Oncology"

DOI: 10.1055/s-0041-1733827

Abstract: Introduction Chromosomal instability is an important feature of hematological cancer. The pathogenesis is complex and it involves genetic and epigenetic factors. As a genetic factor, chromosomal instability may play a key role in leukemogenesis. Accumulation… read more here.

Keywords: complex karyotypes; study; chromosomal instability; hematological cancer ... See more keywords
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Homologous recombination suppresses transgenerational DNA end resection and chromosomal instability in fission yeast

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad160

Abstract: Abstract Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying mechanism remains unclear. Using… read more here.

Keywords: end resection; fission yeast; end; chromosomal instability ... See more keywords